未经证实:2型糖尿病(T2DM)与心脏代谢改变有关,更年期加剧了这些情况,导致心血管疾病(CVD)的风险更大。G蛋白偶联雌激素受体(GPER),介导雌激素的快速作用,对T2DM和更年期都有有益的心脏作用,但是它的作用机制还不清楚。
UNASSIGNED:本研究旨在确定G1作为选择性GPER激动剂是否对T2DM切除卵巢大鼠的心肌脂质代谢具有有益作用。
UnASSIGNED:雌性Wistar大鼠分为5组(每组n=7):假对照(Sh-Ctl),T2DM,卵巢切除-T2DM(OVX-T2DM),OVX-T2DM-G1(GPER激动剂),和OVX-T2DM-车辆(OVX-T2DM-Veh)。T2DM稳定后,G1(200μg/Kg)给药6周。然后,游离脂肪酸(FFA)的水平,CD36,过氧化物酶体增殖物激活受体α(PPARα),并测定心脏组织中的脂质积累。
UNASSIGNED:与Sh-Ctl组相比,心脏FFA(P<0.001),CD36(P<0.05),和脂质积累(P<0.001)增加,T2DM动物心脏PPARα降低(P<0.01);卵巢切除加剧了这些变化。此外,心脏FFA,PPARα,与OVX-T2DM-Veh组相比,OVX-T2DM-G1组的脂质蓄积显著降低(P<0.05)。然而,心脏CD36水平没有变化.
未经证实:G1作为选择性GPER激动剂影响T2DM动物的脂质代谢。它在改善绝经后糖尿病患者的心脏代谢方面也起着至关重要的作用。
UNASSIGNED: Type 2 diabetes mellitus (T2DM) is associated with cardiometabolic changes, and menopause exacerbates these conditions, leading to a greater risk of cardiovascular diseases (CVDs). The G protein-coupled estrogen receptor (GPER), which mediates the rapid effects of estrogen, has beneficial cardiac effects in both T2DM and menopause, but its mechanism of action is not well understood.
UNASSIGNED: This
study aimed to determine whether G1 as a selective GPER-agonist has beneficial effects on cardiac lipid metabolism in ovariectomized rats with T2DM.
UNASSIGNED: Female Wistar rats were divided into 5 groups (n = 7 in each group): Sham-control (Sh-Ctl), T2DM, ovariectomized-T2DM (OVX-T2DM), OVX-T2DM-G1 (GPER-agonist), and OVX-T2DM-vehicle (OVX-T2DM-Veh). After stabilization of T2DM, G1 (200 μg/Kg) was administrated for 6 weeks. Then, the levels of free fatty acids (FFAs), CD36, peroxisome proliferator-activated receptor α (
PPARα), and lipid accumulation in the cardiac tissue were determined.
UNASSIGNED: Compared with the Sh-Ctl group, cardiac FFAs (P < 0.001), CD36 (P < 0.05), and lipid accumulation (P < 0.001) increased, and cardiac
PPARα (P < 0.01) decreased in T2DM animals; ovariectomy intensified these changes. Also, cardiac FFAs,
PPARα, and lipid accumulation (P < 0.05) significantly decreased in the OVX-T2DM-G1 group compared to the OVX-T2DM-Veh group. However, cardiac CD36 levels did not change.
UNASSIGNED: G1 as a selective GPER-agonist affects lipid metabolism in T2DM animals. It also plays a vital role in improving cardiac metabolism during postmenopausal diabetic conditions.