Tuberculosis (TB) is one of the most important infectious diseases and is accounted for as the second most common cause of death due to infectious agents after HIV. It is estimated that a quarter of the world\'s population is infected with Mycobacterium tuberculosis (Mtb), and 5-10% of whom will be infected with active TB. Introducing a biomarker to predict TB can help control the disease and reduces the burden of mortality from this infectious disease. P2X7/P2X7R is one of the most important axes of the innate immune system, which its activity increases the clearance of the residual bacteria in macrophages. Numerous studies have shown the association between rs3751143 polymorphism and susceptibility to TB. The present study aimed to evaluate the diagnostic value of this polymorphism in predicting TB. In the current quantitative analysis, we studied the data from twenty relevant case-control studies, consisting of 10,544 volunteers. We found that, although rs3751143 polymorphism causes susceptibility to TB, but based on statistical analysis, it cannot be considered as a reliable biomarker for the diagnosis of TB.