结核病(TB)是最重要的传染病之一,是仅次于HIV的第二大常见死因。据估计,世界上四分之一的人口感染了结核分枝杆菌(Mtb),5-10%的人将感染活动性结核病。引入生物标志物来预测结核病可以帮助控制疾病并减少这种传染病的死亡负担。P2X7/P2X7R是先天性免疫系统最重要的轴之一,其活性增加了巨噬细胞中残留细菌的清除。大量研究表明rs3751143多态性与结核病易感性之间存在关联。本研究旨在评估该多态性在预测结核病中的诊断价值。在目前的定量分析中,我们研究了20项相关病例对照研究的数据,由10,544名志愿者组成。我们发现,尽管rs3751143多态性导致对结核病的易感性,但根据统计分析,它不能被认为是诊断结核病的可靠生物标志物.
Tuberculosis (TB) is one of the most important infectious diseases and is accounted for as the second most common cause of death due to infectious agents after HIV. It is estimated that a quarter of the world\'s population is infected with Mycobacterium tuberculosis (Mtb), and 5-10% of whom will be infected with active TB. Introducing a biomarker to predict TB can help control the disease and reduces the burden of mortality from this infectious disease.
P2X7/P2X7R is one of the most important axes of the innate immune system, which its activity increases the clearance of the residual bacteria in macrophages. Numerous studies have shown the association between rs3751143 polymorphism and susceptibility to TB. The present study aimed to evaluate the diagnostic value of this polymorphism in predicting TB. In the current quantitative analysis, we studied the data from twenty relevant case-control studies, consisting of 10,544 volunteers. We found that, although rs3751143 polymorphism causes susceptibility to TB, but based on statistical analysis, it cannot be considered as a reliable biomarker for the diagnosis of TB.