背景:使用戊二醛处理的自体心包重建主动脉瓣,也称为Ozaki程序,是主动脉瓣疾病患者的外科手术。已经报道了成年患者的可喜结果,然而,在儿科人群中可获得的数据有限。这项研究观察了在我们研究所接受Ozaki手术的儿童的临床特征和早期结果。
方法:这是对2019年1月至2022年12月在JakayaKikwete心脏研究所(JKCI)接受主动脉瓣重建的儿童进行的回顾性描述性研究。对这些儿童的医疗记录进行了审查,以提取人口统计数据,临床特征,重做手术干预和生存。
结果:在研究期间共有10名儿童接受了Ozaki手术。8名儿童术前出现严重的主动脉瓣反流,2名儿童术前出现严重的主动脉瓣狭窄。手术后,所有儿童均无主动脉瓣反流或无主动脉瓣反流。在整个随访期间,他们都没有重做过手术。没有住院死亡率,然而,一名儿童在手术后一年死亡。平均随访时间为1.6年,最长随访时间为4年。
结论:Ozaki手术在主动脉瓣疾病患儿中显示出令人鼓舞的早期结果。建议使用更大样本量和更长随访时间的未来研究来评估该人群的长期结果。
BACKGROUND: Aortic valve reconstruction using glutaraldehyde-treated autologous pericardium, also called Ozaki procedure, is a surgical procedure for patients with aortic valve disease. Gratifying results have been reported in adult patients, however, limited published data is available in paediatric population. This
study looked at clinical characteristics and early outcomes of children who underwent Ozaki procedure at our Institute.
METHODS: This was a retrospective descriptive
study conducted on children who underwent aortic valve reconstruction at Jakaya Kikwete Cardiac Institute (JKCI) from January 2019 through December 2022. Medical records of these children were reviewed to extract data on demographics, clinical characteristics, redo surgical interventions and survival.
RESULTS: A total of 10 children underwent Ozaki procedure during the
study period. Eight children had severe aortic regurgitation while 2 had severe aortic stenosis preoperatively. All children had either none or trivial aortic regurgitation immediately after surgery. None of them had redone operations throughout the follow-up period. There was no in-hospital mortality, however, one child died one-year after surgery. The mean follow-up period was 1.6 years with the longest follow-up time of 4 years.
CONCLUSIONS: Ozaki procedure showed encouraging early results among children with aortic valve disease who underwent surgical repair by this technique. Future studies with larger sample sizes and longer follow up periods to evaluate long-term results in this population are recommended.