UNASSIGNED:渗透性脱髓鞘综合征(ODS)是由细胞外渗透变化引起的中枢神经系统的非炎症过程,导致少突胶质细胞凋亡和髓鞘破坏,通常影响具有潜在全身性疾病的患者,这些疾病对渗透应激具有敏感性。非霍奇金淋巴瘤(NHL)患者的ODS描述仅限于少数病例报告。
未经评估:这里,我们报告了一名44岁的NHL患者,其偶然诊断为ODS.我们对1959年至2020年NHL患者中已发表的ODS病例进行了文献综述,旨在描述这些患者的特征。
未经评估:共总结了7名患者(4名男性和3名女性),包括我们的病例和6名已发表报告的患者。5例(71.4%)患者报告了体重减轻和酗酒等危险因素。其中6例(85.7%)出现低钠血症,他们都没有过快速的钠校正。四例无症状,弥漫性大B细胞淋巴瘤是NHL最常见的亚型(85.7%)。在大多数情况下,结果是有利的;仅报告了2例与ODS没有直接关系的死亡。
UNASSIGNED:我们希望建议由NHL引起的全身和代谢应激可能与中枢渗透性脱髓鞘的发展有关,因此,NHL可能是ODS的新危险因素。临床医生应该注意血液系统恶性肿瘤患者的ODS,即使没有传统的风险因素。
UNASSIGNED: Osmotic demyelination syndrome (ODS) is a non-inflammatory process of the central nervous system caused by extracellular osmotic changes, which leads to oligodendrocyte apoptosis and disruption of myelin sheaths, usually affecting patients with underlying systemic conditions that impose susceptibility to osmotic stress. Description of ODS in patients with non-Hodgkin lymphoma (NHL) is limited to a few case reports.
UNASSIGNED: Here, we report a 44-year-old man with NHL that had an incidental diagnosis of ODS. We conducted a literature
review of the published cases of ODS in NHL patients from 1959 to 2020, aiming to describe the characteristics of these patients.
UNASSIGNED: A total of seven patients were summarized (four men and three women), including our case and six patients from published reports. Risk factors such as weight loss and alcoholism were reported in five (71.4%) patients. Hyponatremia was found in six (85.7%) of the cases, and none of them had overly rapid sodium correction. Four cases were asymptomatic, and diffuse large B-cell lymphoma was the most common subtype of NHL (85.7%). The outcome was favorable in most cases; only two deaths not directly related to ODS were reported.
UNASSIGNED: We wish to suggest that systemic and metabolic stress induced by NHL may be associated with the development of central osmotic demyelination, and therefore, NHL may be a novel risk factor for ODS. Clinicians should be aware of ODS in patients with hematological malignancies, even in the absence of traditional risk factors.