Orthopaedic surgery

骨科手术
  • 文章类型: Journal Article
    背景:乘坐共享电动踏板车的普及程度上升导致电动踏板车受伤人数增加,现有文献报道录取率增加了350%以上。2023年4月,BroomeShire签署了一份合同,提供300辆电动踏板车,作为共享微移动平台的一部分。这项研究旨在描述人口统计学,布鲁姆地区医院(BRH)出现电动踏板车相关伤害的患者的临床表现和卫生系统利用。
    方法:一项回顾性队列研究检查了2023年4月1日至2024年4月30日期间BRH出现的所有电动踏板车相关损伤。包括急诊科(ED)电子分诊记录中描述的电动踏板车受伤患者。数据来自图表审查。
    结果:在12个月的试验期间,共有190名患者被确定为电动踏板车受伤。平均年龄为26岁,男性和女性人数相等。大多数受伤发生在下午6点至凌晨12点之间(28%),其中53%的患者报告中毒,75%的人没有戴头盔。几乎所有患者(80%)都在急诊科接受治疗,因为他们的受伤严重程度较低。剩下的病人中,22人被录取其中16人被调入三级运营管理。
    结论:用于共享微移动性的电动踏板车的引入代表了与BRH相关的创伤表现的新原因。我们的研究结果提高了人们对布鲁姆电动滑板车受伤的发生率和严重程度的认识。
    BACKGROUND: The rise in popularity of ride share e-scooters has led to an increase in the number of e-scooter injuries, with existing literature reporting increases in rates of admission by more than 350%. In April 2023, the Broome Shire signed a contract to provide 300 e-scooters as part of a shared micro mobility platform. This study aimed to describe the demographics, clinical presentation and health system utilization of patients presenting with e-scooter-related injuries at Broome Regional Hospital (BRH).
    METHODS: A retrospective cohort study examined all e-scooter-related injuries presenting to BRH between April 1st 2023 and April 30th 2024. Patients with e-scooter injuries described in their Emergency Department (ED) electronic triage records were included. Data was collected from chart review.
    RESULTS: A total of 190 patients were identified as having sustained an e-scooter injuries over the 12-month trial period. The median age was 26 years with equal numbers of males and females. Most injuries occurred between 6 pm and 12 am (28%) with 53% of patients reporting being intoxicated, while 75% were not wearing a helmet. Almost all patients (80%) were managed in the emergency department because of the low severity of their injuries. Of the remaining patients, 22 were admitted, with 16 transferred for tertiary-level operative management.
    CONCLUSIONS: The introduction of e-scooters for shared micromobility represents a new cause of trauma related presentations to BRH. Our study\'s results have raised awareness regarding the incidence and severity of electric scooter injuries in Broome.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: Journal Article
    背景:这项研究的目的是评估有抱负的骨科医生对人工智能(AI)的看法,分析性别,人工智能知识,和技术倾向影响对人工智能的看法。此外,评估了最近人工智能进步对职业决策的影响程度。
    方法:向德国骨科协会的学生成员分发了一项数字调查,瑞士,和奥地利。亚组分析探讨了性别,人工智能知识,技术倾向塑造了人们对人工智能的态度。
    结果:在174名受访者中,86.2%(n=150)打算从事骨科手术,并包括在分析中。大多数(74.5%)报告“基本”或“没有”关于AI的知识。大约29.3%的人认为人工智能将在5年内对骨科产生重大影响。另有35.3%的人预计5-10年。人工智能主要被视为辅助工具(77.8%),没有对工作流离失所的重大恐惧。最有价值的人工智能应用被确定为术前植入计划(85.3%),行政任务(84%),和图像分析(81.3%)。人们对过度依赖导致的技能萎缩表示担忧(69.3%),责任(68%),和减少患者的互动(56%)。大多数人对人工智能持“中立”的观点(53%),虽然32.9%的人“热情”。81.9%的人要求医学教育更加重视人工智能。大多数参与者(72.8%)认为最近的人工智能进步并没有改变他们的职业决定,接近或远离骨科专业。统计分析显示AI素养(p=0.015)和技术倾向(p=0.003)之间存在显着关联。医学教育期间AI素养没有显着增加(p=0.091)。
    结论:未来的整形外科医生对人工智能表现出良好的前景,预见其在不久的将来的重大影响。人工智能素养仍然相对较低,在医学院期间没有任何改善。对改善AI相关教育的需求显着。骨科作为专业的选择似乎与最近的AI进步的影响相当强劲。
    方法:横断面调查研究;IV级。
    BACKGROUND: The purpose of this study was to evaluate the perspectives of aspiring orthopaedic surgeons on artificial intelligence (AI), analysing how gender, AI knowledge, and technical inclination influence views on AI. Additionally, the extent to which recent AI advancements sway career decisions was assessed.
    METHODS: A digital survey was distributed to student members of orthopaedic societies across Germany, Switzerland, and Austria. Subgroup analyses explored how gender, AI knowledge, and technical inclination shape attitudes towards AI.
    RESULTS: Of 174 total respondents, 86.2% (n = 150) intended to pursue a career in orthopaedic surgery and were included in the analysis. The majority (74.5%) reported \'basic\' or \'no\' knowledge about AI. Approximately 29.3% believed AI would significantly impact orthopaedics within 5 years, with another 35.3% projecting 5-10 years. AI was predominantly seen as an assistive tool (77.8%), without significant fear of job displacement. The most valued AI applications were identified as preoperative implant planning (85.3%), administrative tasks (84%), and image analysis (81.3%). Concerns arose regarding skill atrophy due to overreliance (69.3%), liability (68%), and diminished patient interaction (56%). The majority maintained a \'neutral\' view on AI (53%), though 32.9% were \'enthusiastic\'. A stronger focus on AI in medical education was requested by 81.9%. Most participants (72.8%) felt recent AI advancements did not alter their career decisions towards or away from the orthopaedic specialty. Statistical analysis revealed a significant association between AI literacy (p = 0.015) and technical inclination (p = 0.003). AI literacy did not increase significantly during medical education (p = 0.091).
    CONCLUSIONS: Future orthopaedic surgeons exhibit a favourable outlook on AI, foreseeing its significant influence in the near future. AI literacy remains relatively low and showed no improvement during medical school. There is notable demand for improved AI-related education. The choice of orthopaedics as a specialty appears to be robust against the sway of recent AI advancements.
    METHODS: Cross-sectional survey study; level IV.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: Journal Article
    白细胞介素-6(IL-6)是响应于组织损伤而释放的细胞因子。创伤患者血清IL-6水平升高与并发症的风险增加有关,例如明显缺氧(SpO2<94%)。急性呼吸窘迫综合征,脂肪栓塞综合征(FES),全身炎症反应综合征,多器官功能障碍综合征和脓毒症。本研究旨在确定血清IL-6作为侵入性骨科手术后并发症的替代生物标志物的作用。
    37名年龄在18至65岁之间接受侵入性骨科手术的成年人被纳入这项以医院为基础的研究。术前连续估计血清IL-6水平,术后24小时和术后7天。监测病例术后并发症。
    血清IL-6水平在术后最初24小时内表现出最大升高,尤其是在老年患者(>60岁)中。接受双极半髋关节置换术治疗股骨颈骨折的老年患者术后IL-6的中位数最高,为258pg/ml。术后24小时测得的血清IL-6水平>130pg/ml可预测术后并发症(敏感性为75%)。在有术后并发症的病例中,最常见的并发症/事件是不明显的缺氧.亚临床FES患者在手术后的前24小时血清IL-6水平最高,中位IL-6水平为300pg/ml(范围为155-444pg/ml)。
    监测血清IL-6水平可能有助于预测和早期发现接受有创骨科手术的患者的术后并发症;可能会提高患者的安全性。
    UNASSIGNED: Interleukin-6 (IL-6) is a cytokine released in response to tissue injury. Elevated serum IL-6 levels in trauma patients have been linked with increased risk of complications such as inapparent hypoxia (SpO2 < 94%), acute respiratory distress syndrome, fat embolism syndrome (FES), systemic inflammatory response syndrome, multiple organ dysfunction syndrome and sepsis. This study aims to determine the role of serum IL-6 as surrogate biomarker of post-operative complications after invasive orthopaedic surgeries.
    UNASSIGNED: Thirty-seven adults between 18 and 65 years of age undergoing invasive orthopaedic surgeries were included in this hospital-based study. Serum IL-6 levels were estimated serially in the pre-operative period, after 24 h and 7 days post-operatively. Cases were monitored for post-operative complications.
    UNASSIGNED: Serum IL-6 levels showed maximum rise in the first 24 h post-operatively especially among older patients (> 60 years). Older patients undergoing bipolar hemiarthroplasty for neck of femur fracture showed highest median post-operative IL-6 level of 258 pg/ml. Serum IL-6 level > 130 pg/ml measured 24 h after surgery was predictive of post-operative complications (sensitivity of 75%). Among the cases with post-operative complications, inapparent hypoxia was the most common complication/event observed. Cases with sub-clinical FES had highest level of serum IL-6 in first 24 h following surgery with median IL-6 level of 300 pg/ml (range 155-444 pg/ml).
    UNASSIGNED: Monitoring serum IL-6 level may help in both anticipation and early detection of post-operative complications in patients undergoing invasive orthopaedic surgeries; potentially enhancing patient safety.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Journal Article
    背景:肥胖是终末期髋关节骨关节炎(OA)的危险因素。虽然全髋关节置换术(THA)通常用于减轻疼痛和改善与OA相关的功能,肥胖与THA后并发症风险增加相关.虽然减肥手术也可以用来减轻体重,减肥手术对THA结局的影响尚不清楚.
    方法:这项回顾性队列分析利用了2003年至2023年的多中心电子病历数据。根据先前的减肥手术对接受THA的肥胖患者进行分层。最终的减肥队列包括451名倾向评分匹配后的患者。在六个队列中比较了并发症发生率和翻修风险,24个月和72个月。其他分析按减重手术和THA之间的间隔对患者进行分层。
    结果:在六个月的随访中,减肥队列的手术部位感染(SSI)的风险显着降低,伤口裂开,深静脉血栓形成(DVT)。24个月时,减重队列的DVT风险较低.在72个月的随访中,减肥队列的翻修率降低,死亡率,心脏病发病率,和Clavien-DindoIV级并发症。
    结论:与未接受减肥手术的匹配队列相比,在THA之前接受减肥手术的肥胖患者在所有时间点的医疗并发症减少,在72个月时的翻修率降低。
    BACKGROUND: Obesity is a risk factor for end-stage hip osteoarthritis. While total hip arthroplasty (THA) is commonly performed to reduce pain and improve function associated with osteoarthritis, obesity has been associated with an increased risk of complications after THA. Although bariatric surgery may also be utilized to reduce weight, the impact of bariatric surgery on THA outcomes remains inadequately understood.
    METHODS: This retrospective cohort analysis utilized multicenter electronic medical record data ranging from 2003 to 2023. Patients who have obesity who underwent THA were stratified based on prior bariatric surgery. The final bariatric cohort comprised 451 patients after propensity score matching. Complication rates and revision risks were compared between cohorts at 6, 24, and 72 months. Additional analysis stratified patients by interval between bariatric surgery and THA.
    RESULTS: At 6-month follow-up, the bariatric cohort had significantly lower risks of surgical site infection, wound dehiscence, and deep vein thrombosis (DVT). At 24 months, the bariatric cohort had a lower risk of DVT. At 72-month follow-up, the bariatric cohort had reduced rates of revision, mortality, cardiac morbidity, and Clavien-Dindo grade IV complications.
    CONCLUSIONS: Obese patients who underwent bariatric surgery prior to THA experienced reduced medical complications at all time points and reduced rates of revision at 72 months relative to a matched cohort who did not undergo bariatric surgery.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: Journal Article
    背景:贫血,失血,输血是骨科大手术患者护理的关键方面。我们评估了医院对指南推荐的患者血液管理(PBM)护理的依从性,分析了医院之间的差异,并验证了接受全膝关节置换术(TKA)或全髋关节置换术(THA)的患者医院PBM性能的两项综合指标。
    方法:这项回顾性队列研究包括2021年在西班牙39家医院进行的所有主要TKA和THA手术。我们使用九项个人质量指标和两种综合质量指标(cQI)评估医院对指南推荐的主要PBM干预措施的依从性:基于机会(cQI1)和全部或无(cQI2)。我们通过使用线性回归分析它们与调整后的总输血指数的关联来验证这些cQI。
    结果:我们纳入了来自33家医院的8561例患者的分析。TKA和THA的PBM护理交付相似。62%的患者接受了分析的PBM干预措施,只有12%的患者接受了完整的PBM途径。较高的医院cQIs评分与较低的调整后总输血指数相关,在TKA和THA。在THA患者中发现cQI1的相关性最大(β=-1.18[95%置信区间-2.00至-0.36];P=0.007)。
    结论:医院在全髋和膝关节置换术中对指南推荐的患者血液管理护理的依从性并不理想,并且各中心各不相同。使用医院中广泛可用的数据,质量指标和综合评分可以成为患者血液管理监测和医疗机构间比较的有价值的工具.
    BACKGROUND: Anaemia, blood loss, and blood transfusion are critical aspects of patient care in major orthopaedic surgery. We assessed hospital adherence to guideline-recommended Patient Blood Management (PBM) care, analysed variations between hospitals, and validated two composite indicators of hospital PBM performance in patients undergoing total knee arthroplasty (TKA) or total hip arthroplasty (THA).
    METHODS: This retrospective cohort study included all primary TKA and THA procedures performed during 2021 across 39 hospitals in Spain. We assessed hospital adherence to key guideline-recommended PBM interventions using nine individual quality indicators and two types of composite quality indicators (cQIs): opportunity-based (cQI1) and all-or-none (cQI2). We validated these cQIs by analysing their associations with the adjusted total transfusion index using linear regression.
    RESULTS: We included 8561 patient episodes from 33 hospitals in the analysis. Delivery of PBM care was similar for TKA and THA. Patients received 62% of the analysed PBM interventions and only 12% of patients underwent the full PBM pathway. Higher hospital cQIs scores were associated with a lower adjusted total transfusion index, both in TKA and THA. The greatest association was found for cQI1 in THA patients (β=-1.18 [95% confidence interval -2.00 to -0.36]; P=0.007).
    CONCLUSIONS: Hospital adherence to guideline-recommended patient blood management care in total hip and knee arthroplasty was suboptimal and varied across centres. Using data that are widely available in hospitals, quality indicators and composite scores could become valuable tools for patient blood management monitoring and comparisons between healthcare organisations.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: Journal Article
    背景:澳大利亚土著(AI)人口面临显著的社会经济劣势,并且与非AI人口相比,其健康结果较差。关于AI人群髋部骨折后的结果的已发表文献很少。
    方法:我们进行了一项回顾性队列研究,比较了在单一区域创伤中心就诊的AI和非AI患者髋部骨折后的结局。感兴趣的主要结果是全因死亡率。次要结果是术后谵妄的几率和住院时间。所有结果均针对收集的基线协变量进行调整。
    结果:125例患者共发现127例髋部骨折。AI组髋部骨折62例,非AI组髋部骨折65例。当比较土著与非土著患者时,全因死亡率的校正风险比(HR)没有统计学意义(HR=2.37,P=0.055)。土著患者术后谵妄的校正几率较低(OR=0.12;P=0.018)。AI队列的中位住院时间延长了4天,校正协变量后无统计学意义。
    结论:有髋部骨折的AI患者更年轻,Charlson合并症指数评分和美国麻醉医师协会评分较高,以及糖尿病和相关终末器官后遗症的发病率较高。全因死亡率没有差异。AI组术后谵妄的几率较低。我们没有发现住院时间有任何差异。
    BACKGROUND: Australian Indigenous (AI) populations face significant socioeconomic disadvantage and have poorer health outcomes when compared to their non-AI counterparts. There is a paucity of published literature on outcomes following hip fracture in the AI population.
    METHODS: We performed a retrospective cohort study comparing outcomes following hip fracture in AI and non- AI patients presenting to a single regional trauma centre. The primary outcome of interest was all-cause mortality. Secondary outcomes of interest were the odds of postoperative delirium and length of stay in hospital. All outcomes were adjusted against collected baseline covariates.
    RESULTS: One hundred and twenty-seven hip fractures were identified across 125 patients. There were 62 hip fractures in the AI group and 65 in the non-AI group. The adjusted hazard ratio (HR) for all-cause mortality was not statistically significant when comparing Indigenous versus non-Indigenous patients (HR = 2.37, P = 0.055). Adjusted odds of postoperative delirium was lower in Indigenous patients (OR = 0.12; P = 0.018). The AI cohort had a 4 day longer median length of stay, which was not statistically significant when adjusted for covariates.
    CONCLUSIONS: AI patients with hip fractures were younger, had a higher Charlson Comorbidity Index Score and American Society of Anaesthesiologists grade, as well as a higher incidence of diabetes and associated end-organ sequalae. There was no difference in all-cause mortality. Odds of postoperative delirium was lower in the AI group. We did not find any difference in the length of hospital stay.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: Journal Article
    使用由半腱肌和股薄肌腱组成的自体绳肌腱移植进行前交叉韧带重建的缺点是肌腱收获引起的疼痛和持续的绳肌无力。在保留肌腱的全内技术中,建议采用4倍半腱肌移植和可调节的皮质环固定术可减少术后屈曲缺陷,同时显示出与传统腿筋技术相似的总体临床结果。然而,有数量有限的高质量研究比较这些技术与不一致的结果.
    为了研究全内(四倍半腱肌)和传统腿筋(双链半腱肌和股薄肌)技术之间的差异,关于(1)自我报告的功能,(2)腿筋力量,和(3)膝盖松弛。
    随机对照试验;证据水平,1.
    总共98名患者被随机分配到全内或传统的腿筋技术。围手术期,获得手术持续时间和移植物大小。国际膝关节文献委员会2000年主观膝关节形式评分,膝关节损伤和骨关节炎结果评分,Tegner活动量表评分,膝关节松弛度(KT-1000关节计左右差和枢轴移位),运动范围,等速膝关节强度,收集术前和术后2年的跳跃测试评分。术后9个月评估恢复运动准备情况。
    共有89名患者完成了2年的随访,45例患者采用全内技术,44例患者采用传统腿筋技术。手术后2年,两组之间的任何结果指标均无显着差异,但是在全内组中有一种趋势是前平移增加(平均,3.6毫米vs2.7毫米),修正手术数量较高(5例vs2例),与传统组相比,更多的患者具有+1和+2枢轴移位值(29例vs18例)。
    全内技术在手术后2年产生与传统的腿筋技术相当的结果,应被视为用于ACL重建的可靠技术。保留股薄肌腱不会导致不太持久的腿筋无力。需要长期随访,以进一步确定术后2年出现的前平移增加的趋势是否会导致更高的移植失败风险。
    UNASSIGNED: A disadvantage of using hamstring tendon autograft consisting of the semitendinosus and gracilis tendons for anterior cruciate ligament reconstruction is pain from tendon harvesting and persistent hamstring weakness. In the tendon-sparing all-inside technique, a quadrupled semitendinosus graft and adjustable-loop cortical fixation are suggested to give less postoperative flexion deficits while displaying overall similar clinical results to the traditional hamstring technique. However, there are a limited number of high-quality studies comparing these techniques with inconsistent results.
    UNASSIGNED: To investigate differences between the all-inside (quadrupled semitendinosus) and traditional hamstring (double-stranded semitendinosus and gracilis) technique regarding (1) self-reported function, (2) hamstring strength, and (3) knee laxity.
    UNASSIGNED: Randomized controlled trial; Level of evidence, 1.
    UNASSIGNED: A total of 98 patients were randomized to either the all-inside or the traditional hamstring technique. Perioperatively, duration of surgery and graft size were obtained. The International Knee Documentation Committee 2000 Subjective Knee Form score, Knee injury and Osteoarthritis Outcome Score, Tegner Activity Scale score, knee laxity (KT-1000 arthrometer side-to-side difference and pivot shift), range of motion, isokinetic knee strength, and hop test score were collected preoperatively and 2 years postoperatively. Return-to-sport readiness was evaluated 9 months postoperatively.
    UNASSIGNED: A total of 89 patients completed 2-year follow-up, 45 patients with the all-inside technique and 44 patients with the traditional hamstring technique. There were no significant differences between groups in any of the outcome measures 2 years after surgery, but there was a tendency in the all-inside group toward having increased anterior translation (mean, 3.6 mm vs 2.7 mm), a higher number of revision surgeries (5 patients vs 2 patients), and more patients having +1 and +2 pivot-shift values (29 vs 18 patients) when compared with the traditional group.
    UNASSIGNED: The all-inside technique yields equivalent results to the traditional hamstring technique 2 years after surgery and should be considered a reliable technique to use for ACL reconstruction. Sparing the gracilis tendon does not lead to less persistent hamstring weakness. Long-term follow-up is needed to further determine whether the tendency of increased anterior translation seen at 2 years postoperatively will lead to a higher risk of graft failure.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: Journal Article
    关于骨骼健康管理的数据有限,包括骨密度(BMD)评估和骨质疏松症(OP)治疗,接受择期骨科手术的患者。
    这是一项回顾性队列研究,使用SymphonyHealth的行政索赔数据,患者年龄≥50岁,有椎体后凸成形术/椎体成形术(KP/VP),全膝关节置换术(TKA),全髋关节置换术(THA)。根据临床实践指南建议,根据索赔数据库中有关感兴趣变量的信息进行风险分层,以识别骨折风险(VHRFx)的患者。
    总共251.919例患者符合纳入标准:KP/VP(31.018),TKA(149.849),和THA(71.052)。大多数是女性(80.3%),平均(SD)年龄为68.5(7.5)岁。接受KP/VP治疗的患者年龄较大,与跌倒风险相关的合并症负担更大。流动性问题,肌肉无力,以及呼吸系统和心血管疾病。手术前6个月,11.8%的患者接受了OP测试和/或治疗。接受KP/VP的患者比接受TKA(11.0%)或THA(10.9%)的患者更有可能接受测试和/或治疗(17.5%)。总的来说,男性的检测和/或治疗率低于女性(4.6%vs13.5%).在手术前的12个月里,诊断为OP且处于VHRFx的患者(30.8%)的治疗和/或检测率高于无OP的患者(11.5%),或在手术前一年没有OP但骨折的人(10.2%)。
    骨健康管理在接受择期骨科手术的患者中是次优的,男性比女性更差。手术前后对OP的适当管理可能会改善预后。
    UNASSIGNED: There are limited data on the management of bone health, including bone mineral density (BMD) evaluation and osteoporosis (OP) treatment, in patients undergoing elective orthopaedic surgeries.
    UNASSIGNED: This was a retrospective cohort study using administrative claims data from Symphony Health, PatientSource for patients aged ≥50 years with documented kyphoplasty/vertebroplasty (KP/VP), total knee arthroplasty (TKA), and total hip arthroplasty (THA). Risk stratification to identify patients at very high risk for fracture (VHRFx) was based on clinical practice guideline recommendations to the extent information on variables of interest were available from the claims database.
    UNASSIGNED: A total of 251 919 patients met inclusion criteria: KP/VP (31 018), TKA (149 849), and THA (71 052). The majority were female (80.3%) with a mean (SD) age of 68.5 (7.5) years. Patients undergoing KP/VP were older and had a greater comorbidity burden associated with risk for falls, mobility issues, muscle weakness, and respiratory and cardiovascular diseases. In the 6 months before surgery, 11.8% of patients were tested and/or received treatment for OP. Patients undergoing KP/VP were more likely to be tested and/or treated (17.5%) than patients undergoing TKA (11.0%) or THA (10.9%). Overall, men had a lower rate of testing and/or treatment than women (4.6% vs 13.5%). In the 12 months before surgery, patients with an OP diagnosis and at VHRFx (30.8%) had a higher rate of treatment and/or testing than those without OP (11.5%), or those without OP but with a fracture in the year preceding surgery (10.2%).
    UNASSIGNED: Bone health management is suboptimal in patients undergoing elective orthopaedic surgeries and is worse in men than in women. Proper management of OP before and after surgery may improve outcomes.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Journal Article
    背景:关于万古霉素(VCM)外用粉剂在减少手术部位感染(SSI)方面的作用的证据不一。
    目的:阐明外用VCM粉预防骨科大手术的效果。
    方法:MEDLINE,Embase,中部,ICTRP,和ClinicalTrials.gov数据库从成立到2023年9月25日进行了搜索。我们纳入了随机对照试验,比较了局部用VCM粉和对照组在大型骨科手术中预防SSI的作用。两名审稿人独立筛选标题和摘要,并提取相关数据,其次是评估偏倚的风险和证据的确定性。主要结果指标是总体SSI,再操作,和不良事件。使用随机效应荟萃分析获得总结结果。我们进行了试验序贯分析(TSA)。
    结果:8项随机对照试验提供了4,307名参与者的数据。VCM粉末在降低总体SSI方面没有差异。在我们的TSA中,患者的累积人数未超过所需的19,233信息大小,Z曲线没有越过试验序贯监测或无效边界,这表明荟萃分析的结果不确定。再次手术没有发现差异。在SSI中,VCM粉末在减少革兰氏阳性球菌SSI方面显示出统计学上的显着差异。然而,这个证据的确定性很低。
    结论:本系统综述和荟萃分析显示,关于VCM粉剂降低骨科大手术中SSI的效果尚无定论。需要使用严格方法的进一步试验来阐明这种干预的效果。
    BACKGROUND: Evidence has been mixed regarding the effect of topical vancomycin (VCM) powder in reducing surgical site infection (SSI).
    OBJECTIVE: To clarify the effect of topical VCM powder for the prevention of SSI in major orthopaedic surgeries.
    METHODS: The MEDLINE, Embase, CENTRAL, ICTRP, and ClinicalTrials.gov databases were searched from their inception to September 25th, 2023. Randomized controlled trials comparing topical VCM powder and controls for the prevention of SSI in major orthopaedic surgeries were included. Two reviewers independently screened the title and abstract and extracted relevant data, followed by the assessment of the risk of bias and the certainty of the evidence. Main outcome measures were overall SSI, reoperation, and adverse events. Summary results were obtained using random-effects meta-analysis. Trial sequential analysis (TSA) was performed.
    RESULTS: Eight randomized controlled trials yielded data on 4307 participants. VCM powder showed no difference in reducing overall SSI. The cumulative number of patients did not exceed the required information size of 19,233 in our TSA, and the Z-curves did not cross the trial sequential monitoring or futility boundary, suggesting an inconclusive result of the meta-analysis. No difference was found for reoperation. Among SSIs, VCM powder showed a statistically significant difference in reducing Gram-positive cocci SSI. However, the certainty of this evidence was very low.
    CONCLUSIONS: This systematic review and meta-analysis suggests inconclusive results regarding the effect of VCM powder in reducing SSI in major orthopaedic surgeries. Further trials using rigorous methodologies are required to elucidate the effect of this intervention.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: Journal Article
    背景:预防性麻醉对老年患者术后神经认知障碍高发率的影响存在争议。氯胺酮预防术后认知功能障碍(POCK)研究旨在评估氯胺酮对这种情况的影响。
    方法:这是一个多中心,随机化,双盲,介入研究。≥60岁接受骨科大手术的患者以1:1的比例随机分配接受术前氯胺酮0.5mg/kg作为静脉推注(n=152)或安慰剂(n=149),随机分组根据研究地点分层,术前认知状态和年龄。主要结果是客观延迟神经认知恢复(dNR)的比例,定义为术后第7天一个或多个神经心理学评估标准偏差的下降。次要结果包括3个月的客观术后神经认知障碍(POND)发生率,以及谵妄,焦虑,手术后七天和三个月出现抑郁症状。
    结果:在包括的301名患者中,292(97%)完成试验。目标dNR发生在氯胺酮组50例(38.8%)和安慰剂组54例(40.9%)患者中(OR[95%CI]0.92[0.56;1.51],p=0.73)在术后第7天。术后3个月客观POND的发生率两组间无显著差异,谵妄发生率也无差异。焦虑,冷漠,和疲劳。术后3个月氯胺酮组抑郁症状发生率较低(OR[95CI]0.34[0.13-0.86])。
    结论:术前单次静脉注射氯胺酮并不能预防老年骨科手术患者dNR或POND的发生。(Clinicaltrials.govNCT02892916。).
    BACKGROUND: Preventive anesthetic impact on the high rates of postoperative neurocognitive disorders in elderly patients is debated. The Prevention of postOperative Cognitive dysfunction by Ketamine (POCK) study aimed to assess the effect of ketamine on this condition.
    METHODS: This is a multicenter, randomized, double-blind, interventional study. Patients ≥60 years undergoing major orthopedic surgery were randomly assigned in a 1:1 ratio to receive preoperative ketamine 0.5 mg/kg as an intravenous bolus (n = 152) or placebo (n = 149) in random blocks stratified according to the study site, preoperative cognitive status and age. The primary outcome was the proportion of objective delayed neurocognitive recovery (dNR) defined as a decline of one or more neuropsychological assessment standard deviations on postoperative day 7. Secondary outcomes included a three-month incidence of objective postoperative neurocognitive disorder (POND), as well as delirium, anxiety, and symptoms of depression seven days and three months after surgery.
    RESULTS: Among 301 patients included, 292 (97%) completed the trial. Objective dNR occurred in 50 (38.8%) patients in the ketamine group and 54 (40.9%) patients in the placebo group (OR [95% CI] 0.92 [0.56; 1.51], p = 0.73) on postoperative day 7. Incidence of objective POND three months after surgery did not differ significantly between the two groups nor did incidence of delirium, anxiety, apathy, and fatigue. Symptoms of depression were less frequent in the ketamine group three months after surgery (OR [95% CI] 0.34 [0.13-0.86]).
    CONCLUSIONS: A single preoperative bolus of intravenous ketamine does not prevent the occurrence of dNR or POND in elderly patients scheduled for major orthopedic surgery. (Clinicaltrials.gov NCT02892916).
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

公众号