■研究2019年原发性冠状病毒病(COVID-19)感染患者视网膜微血管的纵向变化。
■一组参与者,从未感染过COVID-19的人,于2022年12月至2023年5月在北京协和医院招募,中国。参与者接受了全面的眼科检查和眼底成像,其中包括彩色眼底摄影,自发荧光摄影,扫频源光学相干断层扫描(SS-OCT)和SS-OCT血管造影(SS-OCTA)。如果参与者在研究期间感染了COVID-19,在感染恢复后1周和2个月内采用一致的影像学方式进行随访.
■31名患者(61只眼),平均年龄为31.0±7.2岁,有资格参加这项研究。所有参与者在基线数据收集后一个月内感染了轻度COVID-19感染。第一次随访平均感染后10.9±2.0天,第二次随访平均61.0±3.5天。随访期间未观察到临床视网膜微血管病变特征。然而,SS-OCTA分析显示黄斑血管密度(MVD)从基线时的60.76±2.88%显着增加到首次随访时的61.59±3.72%(p=0.015),随后在两个月的随访中恢复到基线水平60.23±3.33%(p=0.162).中央凹无血管区(FAZ)在随访期间保持稳定,基线面积为0.339±0.097mm2,0.342±0.093mm2和0.344±0.098mm2。第一次随访(p=0.09)和第二次随访(p=0.052),分别。中央黄斑厚度,立方体体积和神经节细胞内丛状层在第一次随访时显示出短暂的减少(分别为p<0.001,p=0.039,p=0.002),并在2个月随访时升高至基线水平(分别为p=0.401,p=0.368,p=0.438).
■轻度COVID-19感染可能会暂时和可逆地影响视网膜微血管,以早期恢复阶段视网膜血流短暂增加为特征,感染后两个月恢复到感染前水平。
UNASSIGNED: To investigate the longitudinal alterations of retinal microvasculature in patients with primary coronavirus disease 2019 (COVID-19) infection.
UNASSIGNED: A cohort of participants, who had never been infected with COVID-19, was recruited between December 2022 and May 2023 at Peking Union Medical College Hospital in Beijing, China. Participants underwent comprehensive ophthalmologic examinations and fundus imaging, which included color fundus photography, autofluorescence photography, swept-source optical coherence tomography (SS-OCT) and SS-OCT angiography (SS-OCTA). If participants were infected with COVID-19 during the
study, follow-ups with consistent imaging modality were conducted within one week and two months after recovery from the infection.
UNASSIGNED: 31 patients (61 eyes), with a mean age of 31.0 ± 7.2 years old, were eligible for this
study. All participants contracted mild COVID-19 infection within one month of baseline data collection. The average period was 10.9 ± 2.0 days post-infection for the first follow-up and 61.0 ± 3.5 days for the second follow-up. No clinical retinal microvasculopathy features were observed during the follow-ups. However, SS-OCTA analysis showed a significant increase in macular vessel density (MVD) from 60.76 ± 2.88% at baseline to 61.59 ± 3.72%(p=0.015) at the first follow-up, which subsequently returned to the baseline level of 60.23 ± 3.33% (p=0.162) at the two-month follow-up. The foveal avascular zone (FAZ) remained stable during the follow-ups with areas of 0.339 ± 0.097mm2, 0.342 ± 0.093mm2, and 0.344 ± 0.098mm2 at the baseline, first follow-up (p=0.09) and second follow-up (p=0.052), respectively. Central macular thickness, cube volume and ganglion cell-inner plexiform layer showed a transient decrease at the first follow-up(p<0.001, p=0.039, p=0.002, respectively), and increased to baseline level at the two-month follow-up(p=0.401, p=0.368, p=0.438, respectively).
UNASSIGNED: Mild COVID-19 infection may temporarily and reversibly impact retinal microvasculature, characterized by a transient increase in retinal blood flow during the early recovery phase, which returns to the pre-infection level two months post-infection.