目的:磨牙切牙畸形(MRIM)是一种很少报道的疾病,其特征是第一恒磨牙的根部发育受到干扰。本系统综述旨在整理诊断为MRIM的个体的临床特征。
方法:使用PubMed的系统搜索策略,Embase,WebofScience,和SCOPUS数据库一直进行到2023年3月。纳入标准是病例报告或病例系列,包括与MRIM一致的诊断。使用JoannaBriggsInstitute(JBI)病例报告和病例系列关键评估清单对所有纳入研究进行关键评估,并在JBI统一管理系统中对临床特征进行整理。评估和审查信息计划。
结果:搜索确定了157项研究,其中35项符合纳入标准。经过全文审查,共有23篇论文描述了MRIM牙齿异常,并被纳入本文.共检索到130例报告病例,年龄在3-32岁之间,男性影响1.16:1女性。神经疾病的存在,早产史,药物,合成并描述了生命最初几年内的手术。
结论:MRIM的病因尚未确定,但生命最初几年的重要病史的表观遗传变化可能会影响该根畸形的发展。第一恒磨牙最常见,但是临床医生应该意识到永久性中央切牙,乳牙和其他恒牙也可能受到影响。
Molar-root incisor malformation (MRIM) is a seldom reported condition characterised by disturbances in root development of first permanent molars. This systematic review aimed to collate the clinical characteristics of individuals diagnosed with MRIM.
A systematic search strategy using PubMed, Embase, Web of Science, and SCOPUS databases was performed through to March 2023. Inclusion criteria were
case reports or
case series including a diagnosis consistent with MRIM. Critical appraisal for all included studies utilised the Joanna Briggs Institute (JBI) critical appraisal checklist for
case reports and
case series and collation of clinical characteristics was performed in JBI System for the Unified Management, Assessment and Review of Information program.
The search identified 157 studies from which 35 satisfied the inclusion criteria. After full-text review, a total of 23 papers described the MRIM dental anomaly and were included in this paper. A total of 130 reported cases were retrieved, with age ranging 3-32 years, and males affected 1.16:1 females. Presence of neurological conditions, premature birth history, medication, and surgery within first years of life were synthesised and described.
The aetiology of MRIM is yet to be determined but epigenetic changes from significant medical history in the first years of life are likely to influence the development of this root malformation. First permanent molars were most commonly affected, but clinicians should be aware that permanent central incisors, primary teeth and other permanent teeth may also be affected.