未经证实:脓毒症是一种危及生命的器官功能障碍,原因是宿主对感染的反应失调。及时识别对于降低危重患者的风险和更好的预后很重要。金属蛋白酶1的核小体和组织抑制剂(TIMP1)是生物标志物,其在预测脓毒症器官功能障碍和死亡率方面的有效性和实用性已得到证实。然而,这两种生物标志物在阐明疾病严重程度方面具有更好的预测价值,器官功能障碍,败血症的死亡率还有待回答,需要进一步的研究。
未经证实:80例脓毒症/脓毒性休克患者,这项前瞻性观察试验招募了重症监护病房(ICU)收治的年龄在18~75岁之间的患者.在诊断为脓毒症/脓毒性休克的24小时内,使用酶联免疫吸附测定(ELISA)对血清核小体和TIMP1进行定量。主要结果是比较核小体和TIMP1在估计脓毒症死亡率中的可预测性。
UNASSIGNED:TIMP1和核小体区分幸存者和非幸存者的受试者工作特征曲线下面积(AUROC)为0.70[95%置信区间(CI),0.58-0.81]和0.68(0.56-0.80),分别。虽然独立,TIMP1和核小体具有统计学意义的区分幸存者和非幸存者的能力(分别为p=0.002和p=0.004),未观察到一种生物标志物在区分幸存者和非幸存者方面优于另一种生物标志物.
UNASSIGNED:每种生物标志物的中值显示幸存者和非幸存者之间的统计学显着差异,未观察到一种生物标志物在预测死亡率方面优于另一种生物标志物.然而,这是一项观察性研究,未来需要更大的研究来验证这项研究的结果.
未经批准:RaiN,KhannaP,KashyapS,KashyapL,AnandRK,KumarS.血清核小体和金属蛋白酶组织抑制剂1(TIMP1)预测脓毒症成年危重病患者死亡率的比较:前瞻性观察性研究。印度JCritCareMed2022;26(7):804-810。
UNASSIGNED: Sepsis is a life-threatening organ dysfunction due to dysregulated host response to infection. Timely identification is important for risk reduction and better outcomes in critically ill patients.
Nucleosomes and tissue inhibitors of metalloproteinase1 (TIMP1) are the biomarkers whose validity and utility in predicting organ dysfunction and mortality in sepsis have been proven. However, which biomarker among these two has better predictive value in elucidating disease severity, organ dysfunction, and mortality in sepsis is yet to be answered, and further studies are needed.
UNASSIGNED: Eighty patients with sepsis/septic shock, aged between 18 and 75 years admitted in intensive care unit (ICU) were recruited in this prospective observational
trial. Quantification of serum nucleosomes and TIMP1 was done using enzyme linked immunosorbent assay (ELISA) within 24 hours of diagnosis of sepsis/septic shock. The primary outcome was to compare the predictability of nucleosomes and TIMP1 in estimating sepsis mortality.
UNASSIGNED: The area under the receiver operating characteristic curve (AUROC) for TIMP1 and nucleosomes to discriminate between survivors and non-survivors were 0.70 [95% Confidence interval (CI), 0.58-0.81] and 0.68 (0.56-0.80), respectively. Although independent, TIMP1 and nucleosomes have statistically significant capacity to discriminate between survivors and non-survivors (p = 0.002 and p = 0.004, respectively), superiority of one biomarker over the other in discriminating between survivors and non-survivors was not observed.
UNASSIGNED: The median values of each biomarker showed statistically significant differences between survivors and non-survivors, superiority of one biomarker over other in predicting mortality was not observed. However, this was an observational
study and larger studies are needed in the future to validate the findings of this
study.
UNASSIGNED: Rai N, Khanna P, Kashyap S, Kashyap L, Anand RK, Kumar S. Comparison of Serum Nucleosomes and Tissue Inhibitor of Metalloproteinase1 (TIMP1) in Predicting Mortality in Adult Critically Ill Patients in Sepsis: Prospective Observational
Study. Indian J Crit Care Med 2022;26(7):804-810.