液泡ATP酶(V-ATP酶)是一种质子泵,负责控制细胞的细胞内和细胞外pH值。V-ATPase的结构在所有真核细胞中高度保守,并且涉及物种之间的多种功能。V-ATP酶以其内体和溶酶体的酸化而闻名,并且对于特化细胞的腔酸化也很重要。一些报道表明V-ATPase参与维持碱性细胞内和酸性细胞外pH,从而分别有助于癌细胞的增殖和转移。在癌症中,V-ATPase的表达增加和向质膜的迁移有助于调节关键的致瘤细胞过程,如自噬,Warburg效应,免疫治疗,耐药性和最重要的癌细胞信号。在这次审查中,我们讨论了V-ATPase在酸化和信号通路的间接调节中的直接作用,特别是陷波信号。
The Vacuolar ATPase (V-ATPase) is a proton pump responsible for controlling the intracellular and extracellular pH of cells. The structure of V-ATPase has been highly conserved among all eukaryotic cells and is involved in diverse functions across species. V-ATPase is best known for its acidification of endosomes and lysosomes and is also important for luminal acidification of specialized cells. Several
reports have suggested the involvement of V-ATPase in maintaining an alkaline intracellular and acidic extracellular pH thereby aiding in proliferation and metastasis of cancer cells respectively. Increased expression of V-ATPase and relocation to the plasma membrane aids in cancer modulates key tumorigenic cell processes like autophagy, Warburg effect, immunomoduation, drug resistance and most importantly cancer cell signaling. In this review, we discuss the direct role of V-ATPase in acidification and indirect regulation of signaling pathways, particularly Notch Signaling.