■神经结节病是一种炎性肉芽肿性疾病。只有通过尸检才能发现多达25%的隐匿性结节病影响神经系统。此外,近年来,人们怀疑可溶性白细胞介素2受体(sIL-2R)可能有助于区分神经结节病和神经结节病样疾病,如神经结核,多发性硬化症,或者脑淋巴瘤.
■因此,我们旨在系统回顾随机对照试验(RCT),观察性研究,和病例对照研究评估神经结节病患者sIL-2R水平。
■对于本系统综述,对包括EMBASE在内的电子数据库进行全面的文献检索,WebofScience,科克伦图书馆,MEDLINE,和谷歌学者进行。搜索仅限于1月8日之前的英语和出版日期,2024.
■作为搜索策略的一部分,6条符合纳入标准。两名独立审稿人从每篇文章中提取相关数据。此外,2名独立评审员使用纽卡斯尔-渥太华量表(NOS)评估了每项研究的质量。
■我们纳入了6项研究,包括98名患有神经结节病的患者,525例非结节病患者,和118个健康对照。纳入的研究发表于2010年至2023年之间。脑脊髓液(CSF)sIL-2R水平在神经结节病患者和多发性硬化症之间存在显着差异,血管炎,和健康对照,而血清sIL-2R水平没有显示出足够的辨别力。sIL-2R指数能够区分神经结节病和神经结核,细菌性/病毒性脑膜炎,和健康的控制。
■在这篇系统综述中,我们发现有迹象表明sIL-2R可能是诊断神经结节病的有用生物标志物.为了确定sIL-2R的额外诊断价值,需要进行大型前瞻性研究,不仅要检查血清或CSF中sIL-2R的绝对水平,还要检查其动态变化以及肾功能对sIL-2R水平的影响.
UNASSIGNED: Neurosarcoidosis is an inflammatory granulomatous disease. Up to 25% of occult sarcoidosis affecting the nervous system are only detected by autopsy. In addition, in recent years the suspicion arose that the soluble Interleukin-2 Receptor (sIL-2R) might be useful in differentiating between neurosarcoidosis and neurosarcoidosis-like diseases such as neurotuberculosis, multiple sclerosis, or cerebral lymphoma.
UNASSIGNED: Therefore, we aimed to systematically
review randomized controlled trials (RCT), observational studies, and case-control studies evaluating sIL-2R levels in neurosarcoidosis patients.
UNASSIGNED: For this systematic
review, a comprehensive literature search of electronic databases including EMBASE, The Web Of Science, The Cochrane Library, MEDLINE, and Google Scholar was conducted. The search was limited to the English language and publication date up to January 08th, 2024.
UNASSIGNED: As part of the search strategy conducted, 6 articles met the inclusion criteria. Two independent reviewers extracted the relevant data from each article. In addition, 2 independent reviewers assessed the quality of each study using the Newcastle-Ottawa Scale (NOS).
UNASSIGNED: We included 6 studies comprising 98 patients suffering from neurosarcoidosis, 525 non-sarcoidosis patients, and 118 healthy controls. Included studies were published between 2010 and 2023. Cerebrospinal fluid (CSF) sIL-2R levels differed significantly between neurosarcoidosis patients and multiple sclerosis, vasculitis, and healthy controls whereas serum sIL-2R levels did not reveal sufficient discriminative power. sIL-2R index was able to discriminate neurosarcoidosis from neurotuberculosis, bacterial/viral meningitis, and healthy controls.
UNASSIGNED: In this systematic
review, we found indications that sIL-2R may be a useful biomarker for the diagnosis of
neurosarcoidosis. To determine an additional diagnostic value of sIL-2R, large prospective studies are needed that not only examine absolute sIL-2R levels in serum or CSF but also the dynamic changes as well as the implications of renal function on sIL-2R levels.