肝细胞癌（HCC）是世界上最常见和致命的癌症之一，其特征是复杂的分子致癌作用。神经菌毛蛋白(NRP)NRP1和NRP2是参与与肿瘤进展相关的关键信号通路的多种蛋白的受体。我们旨在系统地回顾所有关于它们在HCC中的作用的现有发现。我们搜查了Scopus,WebofScience(WOS),PubMed,Cochrane和Embase数据库，用于评估临床前或临床HCC模型中NRP的文章。本研究在PROSPERO（CRD42022349774）注册，包括49项研究。多个细胞和分子过程与一个或两个NRP相关，表明它们是HCC患者的潜在诊断和预后生物标志物。主要显示NRP1通过调节几种信号通路促进肿瘤细胞存活和进展。NRP主要调节血管生成,侵袭和迁移，并已显示出诱导侵袭和转移。它们还调节免疫反应和肿瘤微环境，显示出与HCC中缺氧反应和microRNA的关键相互作用。总之,NRP1和NRP2是潜在的生物标志物和治疗靶点，为HCC患者的临床前景提供新的见解。
Hepatocellular carcinoma (HCC) is one of the most common and deadly cancers worldwide and is characterized by complex molecular carcinogenesis.
Neuropilins (NRPs) NRP1 and NRP2 are the receptors of multiple proteins involved in key signaling pathways associated with tumor progression. We aimed to systematically
review all the available findings on their role in HCC. We searched the Scopus, Web of Science (WOS), PubMed, Cochrane and Embase databases for articles evaluating NRPs in preclinical or clinical HCC models. This study was registered in PROSPERO (CRD42022349774) and include 49 studies. Multiple cellular and molecular processes have been associated with one or both NRPs, indicating that they are potential diagnostic and prognostic biomarkers in HCC patients. Mainly NRP1 has been shown to promote tumor cell survival and progression by modulating several signaling pathways. NRPs mainly regulate angiogenesis, invasion and migration and have shown to induce invasion and metastasis. They also regulate the immune response and tumor microenvironment, showing a crucial interplay with the hypoxia response and microRNAs in HCC. Altogether, NRP1 and NRP2 are potential biomarkers and therapeutic targets, providing novel insight into the clinical landscape of HCC patients.
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