这篇综述旨在评估纳米材料的潜力,特别是纳米结构脂质载体(NLCs),在缓解与炎症相关疾病相关的挑战方面,特别强调慢性疾病,如关节炎。跨越WebofScience的综合综合评论,PubMed,以及2000年至2023年的其他学术存储库。文章是根据他们对NLC和炎症管理的关注来选择的,利用关键词,如“纳米材料,\"\"靶向给药,“和”关节炎。“排除标准涉及非英语学习或缺乏关于NLC的足够细节的学习。综合数据概述了优点,挑战,以及NLC在解决慢性炎症性疾病方面的前景。这篇综述还探讨了纳米技术的治疗应用,包括靶向药物递送和组织工程,特别关注慢性炎症中复杂的生物反应,通常涉及非甾体抗炎药(NSAIDs)。此外,探索倾向于局部给药方法,以加强对药物浓度的控制,随着脂质纳米粒的回顾,如脂质体和固体脂质纳米颗粒,强调它们在增加药物渗透方面的潜力,同时解决药物负荷不足等挑战。NLC已经成为克服药物输送挑战的有希望的候选人,特别是在关节炎治疗中,重点关注它们在不同脂质组合物中的优势。该综述强调了通过NLC利用在炎症管理方面取得的重大进展,提供对未来研究方向的见解。此外,它有助于纳米医学的不断进步,强调NLC在开发炎症相关疾病的创新治疗方法中的关键作用,特别是关节炎。NLC代表了有效干预的有希望的途径,纳米技术疗法的信号进展。
This
review seeks to assess the potential of nanomaterials, specifically Nano-struc-tured Lipid Carriers (NLCs), in mitigating challenges associated with inflammation-related disorders, with a particular emphasis on chronic ailments like arthritis. A comprehensive lit-erature
review spanning Web of Science, PubMed, and other scholarly repositories from 2000 to 2023 is conducted. Articles are selected based on their focus on NLCs and inflammation management, utilizing keywords, such as \"nanomaterials,\" \"targeted drug delivery,\" and \"ar-thritis.\" Exclusion criteria involve non-English studies or those lacking adequate detail on NLCs. Synthesized data provide an overview of the advantages, challenges, and prospects of NLCs in addressing chronic inflammatory disorders. This
review also examines the therapeu-tic applications of nanotechnology, including targeted drug delivery and tissue engineering, particularly focusing on the intricate biological responses in chronic inflammation, often in-volving Non-Steroidal Anti-Inflammatory Drugs (NSAIDs). Moreover, the exploration ex-tends to topical delivery methods to enhance control over medication concentration, with a
review of lipid nanoparticles, such as liposomes and solid-lipid nanoparticles, highlighting their potential in augmenting drug permeation while addressing challenges like inadequate drug loading. NLCs have emerged as promising candidates for overcoming drug delivery challenges, par-ticularly in arthritis treatment, with a focus on their advantages across diverse lipid composi-tions. The
review underscores significant strides in inflammation management through NLC utilization, offering insights into future research directions. Moreover, it contributes to ongoing advancements in nanomedicine, emphasizing the pivotal role of NLCs in developing innovative therapeutic approaches for inflammation-related dis-orders, particularly arthritis. NLCs represent a promising avenue for effective interventions, signaling progress in nanotechnology-enabled therapeutics.