目的:Favipiravir是一种抗病毒药物,最近用于COVID-19感染。几份报告将favipirravir的摄入量与头发的伍德灯荧光相关联,指甲,和巩膜。本研究旨在阐明阳性率,和favipiravir相关荧光的位点,并通过暴露时间的函数来揭示荧光阳性率的位点特异性变化。
方法:研究人群包括50名患者和50名对照个体。患者组的所有患者都接受了全剂量的favipravir治疗COVID-19感染。50名志愿者作为对照组。伍德的灯检查是在一个完全黑暗的房间里进行的,和阳性率,范围,模式,并记录荧光分布。
结果:伍德的光显示出指甲的荧光,脚趾甲,巩膜,和头发在35(70%),35(70%),22(44%),8名(16%)患者,分别。没有对照个体通过伍德灯测试为阳性。统计分析显示患者组和对照组在指甲中的伍德发光方面存在显著差异(p=.000),脚趾甲(p=.000),巩膜(p=.000)和头发(p=.003)。虽然手指甲,脚趾甲,和头发荧光阳性率下降或停止在91天的favipiravir暴露后,眼部荧光阳性率延长至188天.
结论:这些发现证实favipiravir可能会产生指甲的荧光,巩膜,和头发,从最初的一个月开始,并在暴露于药物后的第二个月和第三个月达到峰值。尽管指甲和头发荧光在3个月后趋于减弱,停止用药后,眼部荧光可能持续超过6个月。
OBJECTIVE: Favipiravir is an antiviral agent, recently used for COVID-19 infections. Several reports associate favipiravir intake with Wood\'s lamp fluorescence of hair, nails, and sclera. The present study was designed to elucidate the positivity rates, and sites of favipiravir-related fluorescence and to unravel the site-specific changes in fluorescence positivity rates by a function of time past exposure.
METHODS: The study population comprised 50 patients and 50 control individuals. All patients in the patient group had received a full dose of favipiravir for COVID-19 infection. Fifty volunteers served as the control group. Wood\'s lamp examination was performed in a completely darkened room, and the positivity rate, extent, pattern, and distribution of fluorescence were recorded.
RESULTS: Wood\'s light revealed fluorescence of the fingernails, toenails, sclera, and hair in 35 (70%), 35 (70%), 22 (44%), and 8 (16%) patients, respectively. No control individual tested positive by Wood\'s lamp. Statistical analysis revealed significant differences between patient and control groups in terms of Wood\'s light luminescence in the fingernails (p = .000), toenails (p = .000), sclera (p = .000) and hair (p = .003). Although fingernail, toenail, and hair fluorescence positivity rates declined or ceased at or after 91 days of favipiravir exposure, ocular fluorescence positivity rates were prolonged up to 188 days.
CONCLUSIONS: These findings confirm that favipiravir may produce fluorescence of nails, sclera, and hair, detectable by Wood\'s light starting from the initial month and peaking at second- and third months following exposure to the medication. Although
nail and hair fluorescence tend to abate after 3 months, ocular fluorescence may persist even longer than 6 months after cessation of the medication.