N-乙酰转移酶10(NAT10)是调节端粒酶活性并参与DNA损伤反应的重要乙酰转移酶,核糖体RNA(rRNA)转录激活,细胞分裂,微管乙酰化,和其他重要的细胞过程。NAT10表达或分布的异常导致诸如Hutchinson-Gilford早衰综合征(HGPS)和各种肿瘤等疾病,有严重的后果。Remodelin,NAT10的抑制剂可以延缓HGPS的进展;已经进行了许多关于其在肿瘤治疗中的作用的研究。NAT10研究的重大突破是发现了N4-乙酰胞苷(ac4C)mRNA修饰,能显著提高mRNA的稳定性和翻译效率。此外,NAT10修饰了ac4C的mRNA,这与肿瘤的发展有关。这里,我们回顾了有关NAT10的相关研究,特别是其在癌症中的作用,为研究人员提供有关该主题的当前知识状态的简明和翔实的摘要。本综述的结论可为肿瘤治疗提供新的方向。
N-acetyltransferase 10 (NAT10) is an important acetyltransferase that regulates telomerase activity and participates in DNA damage reactions, ribosomal RNA (rRNA) transcriptional activation, cell division, microtubule acetylation, and other important cellular processes. Abnormalities in the expression or distribution of NAT10 result in diseases such as Hutchinson-Gilford progeria syndrome (HGPS) and various tumors, with serious consequences. Remodelin, an inhibitor of NAT10, delays HGPS progression; many studies have been conducted on its role in tumor therapy. A major breakthrough in the study of NAT10 was the discovery of mRNA N4-acetylcytidine (ac4C) modification, which can increase mRNA stability and translation efficiency significantly. In addition, NAT10 modifies the mRNA of ac4C, which is associated with tumor development. Here, we present a
review of pertinent studies focusing on NAT10, particularly its role in cancer, to provide researchers with a concise and informative summary of the current state of knowledge about this topic. The conclusions drawn from this
review could provide a new direction for tumor treatment.