目的:肌肉生长抑制素和卵泡抑素是调节肌肉质量的主要激素,以前的研究表明,它们是由阻力训练调节的。因此,我们进行了系统评价和荟萃分析,以研究抵抗训练对成人循环肌生成抑制素和卵泡抑素的影响。
方法:从开始到2022年10月,在PubMed和Webofscience中进行了一项搜索,以确定原始研究,研究阻力训练与不运动的对照组相比的影响。使用随机效应模型计算标准化平均差和95%置信区间(CI)。
结果:共有26项随机研究,包括36项干预措施,涉及768名参与者(18至82岁),纳入荟萃分析。抗阻训练可有效降低肌肉生长抑制素[-1.31(95%CI-1.74至-0.88,p=0.001,26项研究],并增加卵泡抑素[2.04(95%CI:1.51至2.52),p=0.001,14项研究]。亚组分析显示,无论年龄大小,肌肉生长抑制素的显着减少和卵泡抑素的增加。
结论:成人抗阻训练可有效减少肌肉生长抑制素和增加卵泡抑素,这可能有助于抗阻训练对肌肉质量和代谢结果的有益作用。
Myostatin and follistatin are the main hormones for regulating muscle mass, and previous research suggests they are modulated by resistance training. We therefore performed a systematic
review and meta-analysis to investigate the impact of resistance training on circulating
myostatin and follistatin in adults.
A search was conducted in PubMed and Web of science from inception until October 2022 to identify original studies investigating the effects of resistance training compared with controls that did not exercise. Standardized mean differences and 95% confidence intervals (CIs) were calculated using random effects models.
A total 26 randomized studies, including 36 interventions, and involving 768 participants (aged ∼18 - 82 years), were included in the meta-analysis. Resistance training effectively decreased
myostatin [-1.31 (95% CI -1.74 - -0.88, p = 0.001, 26 studies] and increased follistatin [2.04 (95% CI: 1.51 - 2.52), p = 0.001, 14 studies]. Subgroup analyses revealed a significant decrease in
myostatin and increase in follistatin regardless of age.
Resistance training in adults is effective for reducing myostatin and increasing follistatin which may contribute to the beneficial effects of resistance training on muscle mass and metabolic outcomes.