在急性淋巴细胞白血病中很少报道显示吞噬作用的母细胞。我们报告了一例患有t(12;21)(p13;q22)的B淋巴细胞白血病(BLL)儿科病例;TEL-AML1(ETV6-RUNX1)显示白血病母细胞的红细胞吞噬作用和血栓吞噬作用。骨髓穿刺涂片中大约4%的白血病母细胞显示红细胞吞噬作用,血小板,或一个3岁的韩国男孩的核残留物,诊断为BLL。常规细胞遗传学和分子分析显示存在t(12;21)(p13;q22);TEL-AML1(ETV6-RUNX1)。患者对化疗反应良好,处于完全缓解状态。
Blasts showing hemophagocytosis have been very rarely reported in acute lymphoblastic leukemia. We report a pediatric
case of B lymphoblastic leukemia (BLL) with t(12;21)(p13;q22); TEL-AML1 (ETV6-RUNX1) showing erythrophagocytosis and thrombophagocytosis by leukemic blasts. About 4% of the leukemic blasts in marrow aspirate smears showed phagocytosis of erythrocytes, platelets, or nuclear remnants in a 3-year-old Korean boy with a diagnosis of BLL. Conventional cytogenetics and molecular analysis revealed the presence of t(12;21)(p13;q22); TEL-AML1 (ETV6-RUNX1). The patient responded well to chemotherapy and is in a state of complete remission.