肢带肌营养不良(LGMDs)是一组包含超过20个基因的遗传性神经肌肉病症。越来越多的努力用肌肉MRI表征该组。然而,由于复杂性和相似性,MRI模式的解释通常由该领域的专家完成。这里,我们通过评估文献中报道的肌肉模式受累的变异性,提出了LGDM患者肌肉MRI的逐步图像解释.进行了系统评价,开放开始日期至2022年11月,以描述所有LGMDs肌肉MRI模式。88项研究被纳入最终审查。发现数据描述了17种LGMD类型中的15种的肌肉MRI模式。虽然LGMDs的诊断是具有挑战性的,尽管先进的基因检测和其他诊断方式,肌肉MRI显示有助于LGMDs的诊断。为了进一步提高神经肌肉区肌肉MRI的产量,需要进行更大的患者队列。
Limb girdle muscle dystrophies (LGMDs) are a group of inherited neuromuscular disorders comprising more than 20 genes. There have been increasing efforts to characterize this group with Muscle MRI. However, due to the complexity and similarities, the interpretation of the MRI patterns is usually done by experts in the field. Here, we proposed a step-by-step image interpretation of Muscle MRI in LGDM by evaluating the variability of muscle pattern involvement reported in the literature. A systematic
review with an open start date to November 2022 was conducted to describe all LGMDs\' muscle MRI patterns. Eighty-eight studies were included in the final
review. Data were found to describe muscle MRI patterns for 15 out of 17 LGMDs types. Although the diagnosis of LGMDs is challenging despite the advanced genetic testing and other diagnostic modalities, muscle MRI is shown to help in the diagnosis of LGMDs. To further increase the yield for muscle MRI in the neuromuscular field, larger cohorts of patients need to be conducted.