探讨乳腺癌患者(新)辅助化疗期间大负荷力量训练对肌力的影响。身体成分,肌纤维大小,卫星细胞,和肌核。I-III期乳腺癌妇女被随机分配到力量训练组(ST,n=23)在化疗期间每周两次进行有监督的重负荷力量训练,或常规护理对照组(CON,n=17)。测量肌肉力量和身体成分,并在第一个化疗周期(T0)和化疗和训练后(T1)收集股外侧肌的活检。在胸部按压中,ST的肌肉力量比CON的肌肉力量显着增加(ST:10±8%,p<.001,CON:-3±5%,p=.023)和压腿(ST:+11±8%,p<.001,CON:+3±6%,p=.137)。两组均减少了无脂质量(ST:-4.9±4.0%,p<.001,CON:-5.2±4.9%,p=.004),脂肪量增加(ST:+15.3±16.5%,p<.001,CON:+16.3±19.8%,p=.015),组间无显著差异。从T0到T1没有显着变化,两组之间的肌纤维大小也没有显着差异。对于每根纤维的肌核,I型纤维中CON的非统计学显着增加和ST的非统计学显着降低(p=.053)在组间趋于不同。卫星细胞在ST中趋于减少(I型:-14±36%,p=.097,II型:-9±55%,p=.084),CON无变化,组间无差异。化疗期间的力量训练改善了肌肉力量,但没有显着影响身体成分,肌纤维大小,卫星细胞的数量,和肌核细胞与常规护理相比。
To investigate the effects of heavy-load strength training during (neo-)adjuvant chemotherapy in women with breast cancer on muscle strength, body composition, muscle fiber size, satellite cells, and myonuclei. Women with stage I-III breast cancer were randomly assigned to a strength training group (ST, n = 23) performing supervised heavy-load strength training twice a week during chemotherapy, or a usual care control group (CON, n = 17). Muscle strength and body composition were measured and biopsies from m. vastus lateralis collected before the first cycle of chemotherapy (T0) and after chemotherapy and training (T1). Muscle strength increased significantly more in ST than in CON in chest-press (ST: +10 ± 8%, p < .001, CON: -3 ± 5%, p = .023) and leg-press (ST: +11 ± 8%, p < .001, CON: +3 ± 6%, p = .137). Both groups reduced fat-free mass (ST: -4.9 ± 4.0%, p < .001, CON: -5.2 ± 4.9%, p = .004), and increased fat mass (ST: +15.3 ± 16.5%, p < .001, CON: +16.3 ± 19.8%, p = .015) with no significant differences between groups. No significant changes from T0 to T1 and no significant differences between groups were observed in muscle fiber size. For myonuclei per fiber a non-statistically significant increase in CON and a non-statistically significant decrease in ST in type I fibers tended (p = .053) to be different between groups. Satellite cells tended to decrease in ST (type I: -14 ± 36%, p = .097, type II: -9 ± 55%, p = .084), with no changes in CON and no differences between groups. Strength training during chemotherapy improved muscle strength but did not significantly affect body composition, muscle fiber size, numbers of satellite cells, and myonuclei compared to usual care.