帕金森病主要由黑质致密部多巴胺能神经元丢失和α-突触核蛋白积累引起。虽然普遍的共识是几个因素,如衰老,环境因素,线粒体功能障碍,神经毒性α-突触核蛋白的积累,溶酶体和蛋白酶体蛋白降解系统的故障,氧化应激,和神经炎症,参与帕金森病的神经变性过程,所有这些因素触发的确切机制仍然未知。通常,神经毒性化合物,如鱼藤酮,6-羟基多巴胺,1-甲基-4-苯基-1,2,3,6-四氢吡啶(MPTP),1-甲基4-苯基吡啶(mpp),百草枯,和maneb被用于帕金森病的临床前模型阿魏酸通常被称为其学名,4-羟基-3-甲氧基肉桂酸(C10H10O4),天然存在于谷物中,水果,蔬菜,和蜂产品。这种物质对帕金森氏病表现出神经保护作用,因为它具有有趣的潜力,其中包括抗炎和抗氧化品质。这篇综述进一步详细介绍了帕金森病和阿魏酸的神经保护特性,这些特性可能有助于预防这种疾病。
Parkinson\'s disease is predominantly caused by dopaminergic neuron loss in the substantia nigra pars compacta and the accumulation of alpha-synuclein protein. Though the general consensus is that several factors, such as aging, environmental factors, mitochondrial dysfunction, accumulations of neurotoxic alpha-synuclein, malfunctions of the lysosomal and proteasomal protein degradation systems, oxidative stress, and neuroinflammation, are involved in the neurodegeneration process of Parkinson\'s disease, the precise mechanism by which all of these factors are triggered remains unknown. Typically, neurotoxic compounds such as rotenone, 6-hydroxydopamine, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), 1-methyl 4-phenyl pyridinium (mpp+), paraquat, and maneb are used to Preclinical models of Parkinson\'s disease Ferulic acid is often referred to by its scientific name, 4-hydroxy-3-methoxycinnamic acid (C10H10O4), and is found naturally in cereals, fruits, vegetables, and bee products. This substance exhibits neuroprotective effects against Parkinson\'s disease because of its intriguing potential, which includes anti-inflammatory and antioxidant qualities. This review goes into additional detail about Parkinson\'s disease and the neuroprotective properties of ferulic acid that may help prevent the condition.