目的:本研究的目的是调查口服和可注射全身治疗的有效性和安全性,比如甲氨蝶呤,硫唑嘌呤,环孢菌素,托法替尼,baricitinib,皮质类固醇,他汀类药物,锌,apremilast,等。,用于治疗白癜风病变。
方法:包括PubMed、Scopus,和WebofScience进行了精心搜索,寻找从2010年到2023年8月的研究,重点是全身性口服和注射治疗白癜风,使用针对每个数据库定制的全面关键字和搜索语法。提取的关键数据包括研究设计,治疗功效,患者结果,患者满意度,和安全概况。
结果:在总共42项纳入研究中,口服小脉冲皮质类固醇治疗(OMP)是6项研究(14.2%)的主题.米诺环素是五项研究的焦点(11.9%),而甲氨蝶呤,apremilast,和托法替尼分别在4项研究(9.5%)中进行了检查.抗氧化剂和Afamelanotide分别是三项研究的受试者(7.1%)。环孢菌素,辛伐他汀,口服锌,口服皮质类固醇(不包括OMP)和注射,和baricitinib均在两项研究中进行了探索(4.8%).硫唑嘌呤,霉酚酸酯,和Alefacept分别是一项研究的受试者(2.4%)。
结论:系统治疗白癜风已成功控制病变,无明显副作用。OMP,甲氨蝶呤,硫唑嘌呤,环孢菌素,霉酚酸酯,辛伐他汀,Apremilast,米诺环素,Afamelanotide,托法替尼,Baricitinib,抗氧化剂,口服/注射皮质类固醇是有效的治疗方法。然而,口服锌和alefacept没有显示出有效性。
OBJECTIVE: The purpose of this study is to investigate the effectiveness and safety of oral and injectable systemic treatments, such as methotrexate, azathioprine, cyclosporine, tofacitinib, baricitinib, corticosteroids, statins, zinc, apremilast, etc., for treating vitiligo lesions.
METHODS: Databases including PubMed, Scopus, and Web of Science were meticulously searched for studies spanning from 2010 to August 2023, focusing on systemic oral and injectable therapies for vitiligo, using comprehensive keywords and search syntaxes tailored to each database. Key data extracted included study design, treatment efficacy, patient outcomes, patient satisfaction, and safety profiles.
RESULTS: In a total of 42 included studies, oral mini-pulse corticosteroid therapy (OMP) was the subject of six studies (14.2%).
Minocycline was the focus of five studies (11.9%), while methotrexate, apremilast, and tofacitinib each were examined in four studies (9.5%). Antioxidants and Afamelanotide were the subjects of three studies each (7.1%). Cyclosporine, simvastatin, oral zinc, oral corticosteroids (excluding OMP) and injections, and baricitinib were each explored in two studies (4.8%). Azathioprine, mycophenolate mofetil, and Alefacept were the subjects of one study each (2.4%).
CONCLUSIONS: Systemic treatments for vitiligo have been successful in controlling lesions without notable side effects. OMP, Methotrexate, Azathioprine, Cyclosporine, Mycophenolate mofetil, Simvastatin, Apremilast,
Minocycline, Afamelanotide, Tofacitinib, Baricitinib, Antioxidants, and oral/injectable corticosteroids are effective treatment methods. However, oral zinc and alefacept did not show effectiveness.