■MillerFisher综合征(MFS)被认为是格林-巴利综合征(GBS)的罕见变种,一组以典型的共济失调三联症为特征的急性发作性免疫介导的神经病,无反射,和眼瘫.本审查旨在通过收集有关该主题的已发表文章,提供有关该综合征所有方面的详细和最新概况,从最初的描述到与COVID-19相关的最新发展。
■我们搜索了PubMed,Scopus,EMBASE,以及WebofScience数据库和灰色文献,包括来自已确定研究的参考文献,回顾研究,和关于这个主题的会议摘要。我们使用了与“米勒·费希尔综合症”有关的所有MeSH术语,\"\"米勒费希尔,\“\”费希尔综合症,“和”抗GQ1b抗体。\"
■从MFS的初始概况到COVID-19患者的最新诊断记录,在这篇综述中研究和总结了广泛的参考书目。MFS是一种免疫介导的疾病,在感染后最频繁发作。抗神经节苷脂GQ1b抗体,在约85%的患者中检测到,在该综合征的发病机制中发挥作用。通过常规神经影像学检查,MFS通常没有异常。在极少数情况下,神经影像学显示神经根增强和中枢神经系统受累的迹象。MFS中最一致的电生理发现是感觉神经动作电位降低和H反射缺失。尽管MFS通常是自限的,预后良好,罕见的复发形式已被记录。
■本文对MFS进行了最新的叙述性综述,特别强调临床特征,神经生理学,治疗,MFS患者的预后。
UNASSIGNED: Miller Fisher syndrome (MFS) is considered a rare variant of Guillain-Barré syndrome (GBS), a group of acute-onset immune-mediated neuropathies characterized by the classic triad of ataxia, areflexia, and ophthalmoparesis. The present
review aimed to provide a detailed and updated profile of all aspects of the syndrome through a collection of published articles on the subject, ranging from the initial description to recent developments related to COVID-19.
UNASSIGNED: We searched PubMed, Scopus, EMBASE, and Web of Science databases and gray literature, including references from the identified studies,
review studies, and conference abstracts on this topic. We used all MeSH terms pertaining to \"Miller Fisher syndrome,\" \"Miller Fisher,\" \"Fisher syndrome,\" and \"anti-GQ1b antibody.\"
UNASSIGNED: An extensive bibliography was researched and summarized in the
review from an initial profile of MFS since its description to the recent accounts of diagnosis in COVID-19 patients. MFS is an immune-mediated disease with onset most frequently following infection. Anti-ganglioside GQ1b antibodies, detected in ~85% of patients, play a role in the pathogenesis of the syndrome. There are usually no abnormalities in MFS through routine neuroimaging. In rare cases, neuroimaging shows nerve root enhancement and signs of the involvement of the central nervous system. The most consistent electrophysiological findings in MFS are reduced sensory nerve action potentials and absent H reflexes. Although MFS is generally self-limited and has excellent prognosis, rare recurrent forms have been documented.
UNASSIGNED: This article gives an updated narrative
review of MFS with special emphasis on clinical characteristics, neurophysiology, treatment, and prognosis of MFS patients.