■目的是研究微血管浸润(MVI)与肝细胞癌(HCC)中钆乙氧基苄基DTPA增强磁共振成像(Gd-EOB-DTPA增强MRI)的瘤周成像特征之间的关系。
■直到2022年2月24日,PubMed,Embase,和Cochrane图书馆数据库进行了仔细的搜索,以获取相关材料。用于该荟萃分析的软件包为ReviewManager5.4.1、Meta-DiSc1.4和Stata16.0。摘要结果以灵敏度(SEN)表示,特异性(SPE),诊断优势比(DORs),接收器工作特性曲线下面积(AUC),95%置信区间(CI)。使用亚组分析调查异质性的来源。
■在这项荟萃分析中记住了19篇文章的集合:在这些研究中的13项研究中描述了动脉期(AP)的瘤周增强,在所有19项研究中描述了肝胆期(HBP)的瘤周高血压。SEN,SPE,DOR,13项AP瘤周增强研究的AUC为0.59(95%CI,0.41-0.58),0.80(95%CI,0.75-0.85),4(95%CI,3-6),和0.73(95%CI,0.69-0.77),分别。SEN,SPE,DOR,19项关于HBP的瘤周张力低的研究的AUC为0.55(95%CI,0.45-0.64),0.87(95%CI,0.81-0.91),8(95%CI,5-12),和0.80(95%CI,0.76-0.83),分别。对两个成像特征的亚组分析确定了十个和七个潜在的异质性因素,分别。
■AP的瘤周增强和HBP的瘤周张力降低的结果显示SPE高,SEN低。这表明Gd-EOB-DTPA增强MRI的瘤周成像特征可以作为非侵入性,排除诊断预测肝癌术前肝脏MVI。此外,当其他数据可用时,应更新此分析的结果。此外,在未来,如何提高其SEN将是一个新的研究方向。
UNASSIGNED: The aim was to investigate the association between microvascular invasion (MVI) and the peritumoral imaging features of gadolinium ethoxybenzyl DTPA-enhanced magnetic resonance imaging (Gd-EOB-DTPA-enhanced MRI) in hepatocellular carcinoma (HCC).
UNASSIGNED: Up until Feb 24, 2022, the PubMed, Embase, and Cochrane Library databases were carefully searched for relevant material. The software packages utilized for this meta-analysis were
Review Manager 5.4.1, Meta-DiSc 1.4, and Stata16.0. Summary results are presented as sensitivity (SEN), specificity (SPE), diagnostic odds ratios (DORs), area under the receiver operating characteristic curve (AUC), and 95% confidence interval (CI). The sources of heterogeneity were investigated using subgroup analysis.
UNASSIGNED: An aggregate of nineteen articles were remembered for this meta-analysis: peritumoral enhancement on the arterial phase (AP) was described in 13 of these studies and peritumoral hypointensity on the hepatobiliary phase (HBP) in all 19 studies. The SEN, SPE, DOR, and AUC of the 13 investigations on peritumoral enhancement on AP were 0.59 (95% CI, 0.41-0.58), 0.80 (95% CI, 0.75-0.85), 4 (95% CI, 3-6), and 0.73 (95% CI, 0.69-0.77), respectively. The SEN, SPE, DOR, and AUC of 19 studies on peritumoral hypointensity on HBP were 0.55 (95% CI, 0.45-0.64), 0.87 (95% CI, 0.81-0.91), 8 (95% CI, 5-12), and 0.80 (95% CI, 0.76-0.83), respectively. The subgroup analysis of two imaging features identified ten and seven potential factors for heterogeneity, respectively.
UNASSIGNED: The results of peritumoral enhancement on the AP and peritumoral hypointensity on HBP showed high SPE but low SEN. This indicates that the peritumoral imaging features on Gd-EOB-DTPA-enhanced MRI can be used as a noninvasive, excluded diagnosis for predicting hepatic MVI in HCC preoperatively. Moreover, the results of this analysis should be updated when additional data become available. Additionally, in the future, how to improve its SEN will be a new research direction.