妊娠期肥胖和代谢相关脂肪性肝病(MAFLD)构成了常规产前护理的重大问题,随着全球患病率的增加。类似于肥胖,MAFLD与母亲并发症(例如先兆子痫和妊娠糖尿病)的高风险和后代的长期不良健康结果相关。然而,怀孕期间的MAFLD通常被低估,有限的管理/治疗选择。
■PubMed/MEDLINE,EMBASE,和Scopus基于妊娠期肥胖和/或MAFLD的搜索策略进行搜索,以确定相关论文,直至2024年.这篇综述总结了孕妇肥胖与妊娠期MAFLD关系的相关证据。强调了与妊娠期间肥胖和MAFLD相关的潜在病理生理学(例如胰岛素抵抗和脂肪因子分泌失调)相关的关键机制。此外,介绍了妊娠期MAFLD诊断及其并发症的诊断方法.最后,涵盖了未来研究的有希望的相关领域。
■关于产妇肥胖的研究进展,MAFLD,它们对母体和胎儿/后代健康的影响有望改善相关的诊断方法,并导致新的治疗方法。因此,常规实践可以应用更个性化的管理策略,将个性化算法与遗传和/或多生物标志物分析相结合,以指导预防,早期诊断,和治疗。
UNASSIGNED: Obesity and metabolic-associated fatty liver disease (MAFLD) during pregnancy constitute significant problems for routine antenatal care, with increasing prevalence globally. Similar to obesity, MAFLD is associated with a higher risk for maternal complications (e.g. pre-eclampsia and gestational diabetes) and long-term adverse health outcomes for the offspring. However, MAFLD during pregnancy is often under-recognized, with limited management/treatment options.
UNASSIGNED: PubMed/MEDLINE, EMBASE, and Scopus were searched based on a search strategy for obesity and/or MAFLD in pregnancy to identify relevant papers up to 2024. This
review summarizes the pertinent evidence on the relationship between maternal obesity and MAFLD during pregnancy. Key mechanisms implicated in the underlying pathophysiology linking obesity and MAFLD during pregnancy (e.g. insulin resistance and dysregulated adipokine secretion) are highlighted. Moreover, a diagnostic approach for MAFLD diagnosis during pregnancy and its complications are presented. Finally, promising relevant areas for future research are covered.
UNASSIGNED: Research progress regarding maternal obesity, MAFLD, and their impact on maternal and fetal/offspring health is expected to improve the relevant diagnostic methods and lead to novel treatments. Thus, routine practice could apply more personalized management strategies, incorporating individualized algorithms with genetic and/or multi-biomarker profiling to guide prevention, early diagnosis, and treatment.