睑板腺存在于睑结膜下方;因此,没有红外成像,肉眼是看不见的。这项研究使用动脉造影对睑板腺功能障碍(MGD)的患者进行了分组,并评估了两组中热按摩和机械挤压的效果。
MGD患者分为两组,根据睑板腺缺失程度:第1组,眼睑评分总和为0~4分(轻度至中度腺体缺失),第2组,眼睑评分总和为5~6分(重度腺体缺失)。两组均给予高温按摩和机械挤压,每周1次,共4周。并且仅允许使用非防腐剂人工泪液。眼表疾病指数(OSDI),Schirmer\'stest,介体图评分,泪液破裂时间(TBUT),眼表染色,可表达睑板腺,并对治疗前后的质量进行比较。
在完成4周治疗和第5周评估的49名患者中,29名被分配到第1组,20名被分配到第2组。裁图评分,OSDI,TBUT,两组治疗前后美脂的表达均有显著性差异。然而,治疗后第1组和第2组的临床体征变化无明显差异。没有分组,所有患者均显示出甲动脉造影评分显着下降,OSDI,角膜染色评分,治疗后TBUT和meibum的可表达性增加。
考虑到当前研究的结果,热按摩和机械挤压可能是有效的患者睑板腺损失,无论严重程度如何。
Meibomian glands exist beneath the palpebral conjunctiva; thus, it is invisible to the naked eye without infrared imaging. This study used meibography to group patients with meibomian gland dysfunction (MGD) and assessed the effects of hyperthermic massage and mechanical squeezing in both groups.
Patients with MGD were divided into two groups, according to the degree of meibomian gland loss: group 1, in which the sum of eyelid scores ranged from 0 to 4 (mild to moderate gland loss) and group 2, in which the sum of eyelid scores ranged from 5 to 6 (severe gland loss). Hyperthermic massage and mechanical squeezing were given to both groups once a week for 4 weeks, and only non-preservative artificial tears were allowed. Ocular surface disease index (OSDI), Schirmer\'s test, meibography score, tear break-up time (TBUT), ocular surface staining, expressible meibomian gland, and quality before and after treatment were compared.
Of the 49 patients who completed the 4 weeks of treatment and the evaluation at week 5, 29 were assigned to group 1 and 20 were assigned to group 2. Meibography scores, OSDI, TBUT, and expressibility of meibum had significant differences before and after treatments in both groups. However, there was no significant difference between the changes in clinical signs between group 1 and 2 after treatment. Without grouping, all patients showed significant decreases in meibography score, OSDI, cornea staining score, and increases in TBUT and expressibility of meibum after treatment.
Considering the results of the current study, hyperthermic massage and mechanical squeezing may be effective in patients with meibomian gland loss, regardless of the degree of severity.