背景:血清阳性率研究提供了有关感染的真实程度的信息,并捕获了人口统计学和地理差异,表明对严重急性呼吸系统综合症冠状病毒2(SARS-CoV-2)的免疫水平。我们试图在马普托市和省的课堂教学中提供学龄儿童接触SARS-CoV-2的当地证据,莫桑比克。
方法:在2022年8月至11月之间,我们对农村四所学校的学龄儿童进行了横断面研究,城郊,以及马普托市和省的城市地区。即时测试用于评估SARS-CoV-2抗原和抗SARS-CoV-2特异性免疫球蛋白M(IgM)和免疫球蛋白G(IgG)抗体。使用描述性统计来估计抗原和抗体的患病率。使用多元逻辑回归模型来估计与抗SARS-CoV-2抗体相关因素的校正比值比(AOR)。
结果:共分析了736名学龄儿童。SARS-CoV-2抗原的患病率为0.5%(4/736)。SARS-CoV-2抗原的患病率为0.0%(0/245),0.8%(2/240)和0.8%(2/251),在农村,分别是城市周边地区和城市地区。抗SARS-CoV-2抗体(IgG或IgM)的总血清阳性率为80.7%(594/736)。农村地区抗SARS-CoV-2IgG或IgM抗体检出率为76.7%(188/245),在城市周边地区检测到80.0%(192/240),在城市地区检测到85.3%(214/251)。在调整后的逻辑回归模型中,与来自农村地区的学龄儿童相比,来自城市地区的学龄儿童更有可能感染抗SARS-CoV-2IgG或IgM抗体(调整后比值比:1.679;95%CI:1.060-2.684;p值=0.028).
结论:在课堂教学期间,观察到学龄儿童中活跃的SARS-CoV-2病例。超过一半的学龄儿童暴露于SARS-CoV-2,而SARS-CoV-2在城市地区的学校中比在马普托市和省的农村地区的学校中更为普遍。
BACKGROUND: Seroprevalence studies provide information on the true extent of infection and capture demographic and geographic differences, indicating the level of immunity against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). We sought to provide local evidence of SARS-CoV-2 exposure in school-aged children during in-class teaching in Maputo City and Province, Mozambique.
METHODS: Between August and November 2022, we performed a cross-sectional
study in school-aged children in four schools in rural, peri-urban, and urban areas of Maputo City and Province. A point-of-care test was used to evaluate SARS-CoV-2 antigens and anti-SARS-CoV-2-specific immunoglobulin M (IgM) and immunoglobulin G (IgG) antibodies. Descriptive statistics were used to estimate the prevalence of the antigens and antibodies. Multiple logistic regression models were used to estimate the adjusted odds ratio (AOR) for the factors associated with anti-SARS-CoV-2 antibodies.
RESULTS: A total of 736 school-aged children were analyzed. The prevalence of the SARS-CoV-2 antigen was 0.5% (4/736). The prevalence of SARS-CoV-2 antigens was 0.0% (0/245), 0.8% (2/240) and 0.8% (2/251), in the rural, peri-urban and urban areas respectively. The overall seroprevalence of the anti-SARS-CoV-2 antibodies (IgG or IgM) was 80.7% (594/736). In rural area anti-SARS-CoV-2 IgG or IgM antibodies were detected in 76.7% (188/245), while in peri-urban area they were detected in 80.0% (192/240) and in urban area they were detected in 85.3% (214/251). In the adjusted logistic regression model, school-aged children from the urban area were more likely to have anti-SARS-CoV-2 IgG or IgM antibodies than were school-aged children from the rural area (adjusted odds ratio: 1.679; 95% CI: 1.060-2.684; p-value = 0.028).
CONCLUSIONS: During the in-class teaching period, active SARS-CoV-2 cases in school-aged children were observed. More than half of the school-aged children were exposed to SARS-CoV-2, and SARS-CoV-2 was significantly more common in the schools at the urban area than in the school in the rural area at Maputo City and Province.