未经证实:特发性膜性肾病(iMN)是肾病综合征的主要原因。不典型膜性肾病(aMN)是我国一种新型的肾病,以免疫荧光检查为特征,那就是IgG,IgA,IgM,C3,C1q阳性,但没有次要原因的临床证据.磷脂酶A2受体(PLA2R)是iMN患者的主要靶抗原。甘露糖结合凝集素(MBL)途径的激活在MN的发展中起着至关重要的作用。我们的目的是研究PLA2R和MBL在iMN和aMN发病机制中的作用。
UNASSIGNED:我们进行了一项回顾性观察研究,使用按年龄匹配的倾向评分,性别,和eGFR。所有临床,实验室数据,并收集患者的随访资料。检测抗PLA2R抗体和MBL的血清水平。
未经评估:最后,包括30例iMN患者和30例aMN患者,本研究回顾性收集了20名健康对照.在iMN和aMN组中,抗PLA2R()患者的24h蛋白尿水平高于抗PLA2R(-)患者,血清白蛋白低于抗PLA2R(-)患者。在AMN患者中,抗PLA2R(+)患者的MBL水平显著高于抗PLA2R(-)患者(p=0.045)。iMN和aMN组血清抗PLA2R水平与未缓解呈正相关。
未经证实:补体凝集素途径与MN的发展有关联,尤其是抗PLA2R抗体阳性的患者。血清MBL不能区分两种疾病。血清MBL水平与临床表现无关,也没有预后。
UNASSIGNED: Idiopathic membranous nephropathy (iMN) is a major cause of nephrotic syndrome. Atypical membranous nephropathy (aMN) is a new type of nephropathy in China, characterized by a \'full-house\' on immunofluorescent examination, that is IgG, IgA, IgM, C3, C1q positive, but without clinical evidence of a secondary cause. Phospholipase A2 receptor (PLA2R) was the major target antigens in iMN patients. Activation of the mannose-binding lectin (MBL) pathway plays a vital role in the development of MN. Our objective was to investigate the role of PLA2R and MBL in the pathogenesis of iMN and aMN.
UNASSIGNED: We conducted a retrospective observational
study using propensity score matching by age, gender, and eGFR. All clinical, laboratory data, and follow-up data of the patients were collected. Serum levels of anti-PLA2R antibodies and MBL were tested.
UNASSIGNED: Finally, 30 iMN patients and 30 aMN patients were included, and 20 healthy controls were retrospectively collected in this
study. The 24 h proteinuria level was higher and serum albumin was lower in anti-PLA2R (+) patients than in anti-PLA2R (-) patients in both iMN and aMN groups. In aMN patients, MBL levels were significantly higher in anti-PLA2R (+) patients than in anti-PLA2R (-) patients (p = .045). The serum level of anti-PLA2R positively correlated with no-remission in both iMN and aMN groups.
UNASSIGNED: The complement lectin pathway has an association with the development of MN, especially in patients with positive anti-PLA2R antibodies. Serum MBL cannot differentiate between the two diseases. Serum MBL levels are not associated with clinical manifestations, nor with prognosis.