目的:口腔恶性黑色素瘤(OMM)是由黑素细胞增殖引起的一种罕见且侵袭性的恶性肿瘤,仅占所有口腔恶性肿瘤的0.5%。它是侵入性的并且倾向于转移。这项研究的目的是确定OMM的患者概况,并提供有关该疾病的临床特征和治疗计划的信息。
方法:在Pubmed数据库中搜索最近10年作为病例报告发表的OMM病例。搜索仅限于英语和开放获取的病例报告。对43例病例报告中45例患者的49例OMM进行分析。除了年龄,性别,患者的吸烟和饮酒习惯,关于OMM的症状和体征的数据,病变的位置,用于诊断和治疗的成像模式,淋巴结受累,转移的存在,生存时间,并记录治疗方式。
结果:在OMM病例中,18(40%)的患者是女性,27(60%)为男性,平均年龄为53.13±16.09岁。最常见的症状是“肿胀”(n=23,33.8%),最常见的症状是“色素沉着”(n=40,24.4%)。OMM的最常见部位是上颌骨(n=21,占46.7%)。根据病例中成像方式的使用率,确定主要使用“高级成像方式”(n=24,53.3%).确定22.2%(n=10)的患者在前5年内死亡。综合治疗(n=21,46.5%)主要应用于患者。
结论:OMM在上颌骨更为常见,在男性和生命的第五个十年中,和先进的成像方式最常用于检测疾病。由于其预后不良,了解OMM的患者概况和常见临床特征将提高医生的临床意识。
OBJECTIVE: Oral malignant melanoma (OMM) is a rare and aggressive malignant tumour arising from the proliferation of melanocytes and accounts for only 0.5 % of all oral malignancies. It is invasive and tends to metastasise. The aim of this study is to determine the patient profile of OMM and to provide information about the clinical features and treatment plans of the disease.
METHODS: The Pubmed database was searched for OMM cases published as case reports in the last 10 years. The search was limited to English and open-access case reports. A total of 49 OMMs in 45 patients from 43 case reports were analyzed. In addition to the age, gender, smoking and alcohol consumption habits of the patients, data on the signs and symptoms of OMM, location of the lesion, imaging modalities used in diagnosis and treatment, lymph node involvement, presence of metastasis, survival time, and treatment modalities were recorded.
RESULTS: In OMM cases, 18 (40 %) of the patients were female, 27 (60 %) were male, and the mean age was 53.13 ± 16.09 years. The most common symptom was \"swelling\" (n = 23, 33.8 %) and the most common finding was \"hyperpigmentation\" (n = 40, 24.4 %). The most common site of OMM was the maxilla (n = 21, 46.7 %). According to the rate of use of imaging modalities in the cases, it was determined that \"advanced imaging modalities\" were mostly used (n = 24, 53.3 %). It was determined that 22.2 % (n = 10) of the patients died within the first 5 years. Combined treatment (n = 21, 46.5 %) were mostly applied to the patients.
CONCLUSIONS: OMM is more common in the maxilla, in males and in the fifth decade of life, and advanced imaging modalities are most commonly used to detect the disease. Because of its poor prognosis, knowing the patient profile and common clinical features of OMM will increase the clinical awareness of physicians.