自适应放射治疗有可能减少边缘,提高目标覆盖率,并通过优化每日解剖变化的辐射递送来降低对危险器官(OAR)的毒性。考虑到在重新照射的情况下对正常组织的风险,在确定性照射后对局部复发性前列腺癌的挽救仍然是具有挑战性的临床方案。这里,我们提供了一个病例系列,包括5例局部复发性前列腺癌患者,这些患者接受了自适应在线直线加速器或基于3-TMR的直线加速器治疗,以证明其具有优异的目标覆盖率.所有患者均以可接受的急性毒性完成了计划的治疗过程,但短暂的随访时间并未告知亚急性/晚期毒性。
Adaptive radiotherapy has the potential to reduce margins, improve target coverage, and decrease toxicity to organs at risk (OARs) by optimizing radiation delivery to daily anatomic changes. Salvage for locally recurrent prostate cancer after definitive radiation remains a challenging clinical scenario given the risks to normal tissue in a setting of re-irradiation. Here, we present a
case series of five patients with locally recurrent prostate cancer treated with an adaptive online linear accelerator or a 3-T MR-based linear accelerator to demonstrate excellent target coverage. All patients completed the planned treatment course with acceptable acute toxicities but a short follow-up time does not inform subacute/late toxicities.