炎症是心血管结局的关键决定因素,但其在心力衰竭中的作用尚不确定。在前瞻性的心脏代谢疾病患者中,CIRT(心血管炎症减少试验)的多中心辅助研究,CIRT-CFR(评估心血管炎症的冠状动脉血流储备),尽管血脂控制良好,但冠状动脉血流储备受损与炎症和心肌应变增加独立相关,血糖,和血液动力学曲线。炎症改变了CFR与心肌劳损的关系,破坏心脏血流和功能之间的联系。需要进一步的研究来研究早期炎症介导的CFR捕获微血管缺血的减少是否可能导致心脏代谢疾病患者的心力衰竭。(心血管炎症减少试验[CIRT];NCT01594333;评估心血管炎症的冠状动脉血流储备[CIRT-CFR];NCT02786134)。
Inflammation is a key determinant of cardiovascular outcomes, but its role in heart failure is uncertain. In patients with cardiometabolic disease enrolled in the prospective, multicenter ancillary
study of CIRT (Cardiovascular Inflammation Reduction
Trial), CIRT-CFR (Coronary Flow Reserve to Assess Cardiovascular Inflammation), impaired coronary flow reserve was independently associated with increased inflammation and myocardial strain despite well-controlled lipid, glycemic, and hemodynamic profiles. Inflammation modified the relationship between CFR and myocardial strain, disrupting the association between cardiac blood flow and function. Future studies are needed to investigate whether an early inflammation-mediated reduction in CFR capturing microvascular ischemia may lead to heart failure in patients with cardiometabolic disease. (Cardiovascular Inflammation Reduction
Trial [CIRT]; NCT01594333; Coronary Flow Reserve to Assess Cardiovascular Inflammation [CIRT-CFR]; NCT02786134).