近年来,胃癌的免疫治疗取得了突破性进展。随着免疫检查点抑制剂的出现,阻断体内的抑制性分子可以重新激活免疫系统来抵抗肿瘤,这大大提高了胃癌患者的生存率。淋巴细胞活化基因-3(LAG-3),又称CD223,是一种免疫检查点受体蛋白,主要表达于活化的免疫细胞,具有维持内环境稳定和免疫调节功能,与肿瘤的发生发展密切相关。因此,LAG-3可作为肿瘤免疫治疗的新靶点。在这篇叙述性评论中,结构,免疫功能,探讨LAG-3免疫检查点在胃癌中的研究进展,为胃癌的进一步研究和免疫治疗提供参考。
In recent years, the immunotherapy of gastric cancer has made a breakthrough. With the emergence of immune checkpoint inhibitors, blocking the inhibitory molecules in the body can reactivate the immune system to resist tumors, which dramatically improves the survival rate of gastric cancer patients. Lymphocyte activation gene-3 (LAG-3), also known as CD223, is a kind of immune checkpoint receptor protein, mainly expressed in activated immune cells, and it has the functions of maintaining internal environment stability and immunological regulation and is closely related to the occurrence and development of tumor. Therefore, LAG-3 can be used as a new target for tumor immunotherapy. In this narrative
review, the structure, immunological function, and research progress of immune checkpoint LAG-3 in gastric cancer is explored to provide a reference for further research and immunotherapy of gastric cancer.