枸杞多糖(LBP)和锌对肝损伤均有保护作用。在本文中,LBP和ZnSO4联合应用研究其对酒精性肝损伤的预防作用。将大鼠分成六组,正常组,酒精组,硫酸锌组，LBP组,低剂量组ZnSO4，高剂量组ZnSO4和LBP，用于探讨LBP和ZnSO4复合物对酒精肝脏脂质代谢的影响,酒精代谢酶，氧化损伤，和肝脏的炎症。通过灌胃处理建立实验模型,观察,并对大鼠的各项指标进行测定。结果表明，LBP和ZnSO4的组合可以显着降低甘油三酯（TG）的水平，总胆固醇(TC),肿瘤坏死因子-α丙二醛（MDA），丙氨酸氨基转移酶（ALT），天冬氨酸转氨酶（AST），和酶亚型2E1（CYP2E1）的活性。它还显着增加了总超氧化物歧化酶（SOD）的活性，过氧化氢酶(CAT),谷胱甘肽过氧化物酶（GSH-Px），谷胱甘肽肽（GSH），和酒精脱氢酶,有效改善肝组织病变。更重要的是，LBP和ZnSO4的组合对酒精性脂肪肝的缓解具有协同作用，通过促进脂质代谢减轻慢性酒精性肝损伤，抑制氧化应激，控制炎症反应，并调节大鼠体内酒精代谢酶的表达和活性。
Both Lycium barbarum L. polysaccharides (LBP) and zinc have protective effects on liver injuries. In this paper, LBP and ZnSO4 were combined to
study the effects on the prevention of alcoholic liver injury. The rats were divided into six groups, the normal group, alcohol group, zinc sulfate group, LBP group, low-dose group of ZnSO4, and high-dose group of ZnSO4 and LBP, used to explore the impact of LBP and ZnSO4 complex on liver lipid metabolism of alcohol, alcohol-metabolizing enzymes, oxidative damage, and inflammation of the liver. The experimental model was established by gavage treatment, observation, and determination of indexes of rats. The results showed that the combination of LBP and ZnSO4 could significantly decrease the levels of triglyceride (TG), total cholesterol (TC), tumor necrosis factor-α(TNF-ɑ), malondialdehyde (MDA), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and the activity of enzyme subtype 2E1 (CYP2E1). It also significantly increased the activities of total superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione peptide (GSH), and alcohol dehydrogenase, effectively improved the liver tissue lesion. What is more, the combination of LBP and ZnSO4 had a synergistic effect on the remission of alcoholic fatty liver, and alleviated chronic alcoholic liver injury by promoting lipid metabolism, inhibiting oxidative stress, controlling inflammatory responses, and regulating the expression and activity of alcohol-metabolizing enzymes in rats.
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