背景:印度目前正面临2型糖尿病(T2DM)和肥胖症的流行,这是非酒精性脂肪性肝病(NAFLD)发展的高风险因素。一种非侵入性工具,振动控制瞬态弹性成像(VCTE;FibroScan,回声,巴黎,法国)用于诊断NAFLD。
目的:为了确定患病率,光谱,使用肝功能测试(LFT)和非侵入性FibroScan(肝脏硬度测量,即,LSM评分)通过Belagavi市的基于人群的横断面研究对肝脏进行分析。
方法:对有详细病史的受试者进行肝病筛查,人体测量,LFTs,血糖,和肝脏的FibroScan评估肝脏脂肪变性和肝纤维化。
结果:该研究包括2448名女性,其中860名(35.13%)患有FibroScan检测到的NAFLD(受控衰减参数{CAP}≥275dB/m)。几乎,58.8%的T2DM患者患有NAFLD。NAFLD患者的BMI和腰围较高。当应用单变量逻辑回归时,T2DM患者的CAP≥275dB/m的可能性为14.5倍(95%CI,4.55,6.52).同样,BMI>23mg/m2的患者发生CAP≥275dB/m的可能性增加1.34倍(95%CI,1.68,2.37).NAFLD的风险每增加1%。
结论:女性的NAFLD是印度最常见的非传染性疾病;在本研究中,女性的患病率为35.13%。BMI较高,代谢危险因素的存在,年龄增加与女性发生NAFLD的高风险相关.
BACKGROUND: India is currently facing an epidemic of type 2 diabetes mellitus (T2DM) and obesity which are high-risk factors for the development of non-alcoholic fatty liver disease (NAFLD). A non-invasive tool, the vibration-controlled transient elastography (VCTE; FibroScan, Echosens, Paris, France) is used to diagnose NAFLD.
OBJECTIVE: To identify the prevalence, spectrum, and metabolic determinants of NAFLD in Indian adult women using liver function tests (LFT) and non-invasive FibroScan (liver stiffness measure, i.e., LSM score) of the liver through a cross-sectional population-based
study in the city of Belagavi.
METHODS: The subjects were screened for the presence of liver disease with a detailed history, anthropometric measurements, LFTs, blood sugars, and FibroScan of the liver to assess liver steatosis and liver fibrosis.
RESULTS: The
study included 2448 women with 860 (35.13%) having NAFLD (controlled attenuation parameter {CAP}≥275 dB/m) as detected by FibroScan. Nearly, 58.8% of the participants with T2DM had NAFLD. Participants with NAFLD had higher BMI and waist circumference. When univariate logistic regression was applied, those with T2DM were 14.5 times (95% CI, 4.55, 6.52) likely to have CAP≥275 dB/m. Similarly, those with higher BMI>23 mg/m2 were 1.34 (95% CI, 1.68, 2.37) times more likely to have CAP ≥275 dB/m. The risk of NAFLD increases by ~1% for every one-year increase in age.
CONCLUSIONS: NAFLD in women is the most common non‑communicable disease in India; a prevalence of 35.13% was observed in the present
study in women. Higher BMI, presence of metabolic risk factors, and incremental age were associated with a high risk of developing NAFLD in women.