背景:高甘油三酯血症(HTg)定义为血液中甘油三酯(TG)的高量,随着时间的推移会导致严重的并发症。HTg通常是代谢紊乱的一部分,如糖尿病,代谢综合征,和血脂异常。不同的药物已经被用来治疗HTg,但实验,许多草药已被推荐用于治疗HTg作为辅助疗法。在大多数情况下,这些建议是基于动物研究,关于其机制和临床应用的证据有限。
目的:本综述主要针对具有降低TG作用的中药。
方法:搜索是在PubMed中进行的,科学直接,Scopus,WebofScience和GoogleScholar数据库在1997年至2017年之间的20年期间,使用关键词搜索药用植物,植物提取物,高甘油三酯血症,血脂异常,高脂血症,脂蛋白脂肪酶和载脂蛋白。
结果:根据结果,许多植物表现出积极的影响,但葱葱,Nigellasativa,姜黄,Anethumgraveolens和Commiphoramukul具有最佳的TG降低效果,并具有确切的作用机制。
结论:似乎使用这些植物作为补充疗法或提取其活性成分以及目前可用的药物将改善患者的HTg管理。
BACKGROUND: Hypertriglyceridemia (HTg) defines as high amounts of triglyceride (TG) in the blood which can lead to serious complications over time. HTg is usually a part of metabolic disorders such as diabetes mellitus, metabolic syndrome, and dyslipidemia. Different medications have been used to treat HTg but experimentally, many herbs have been recommended for treating HTg as an adjuvant therapy. In most cases, the recommendations are based on animal studies and limited evidences exist about their mechanisms and clinical usefulness.
OBJECTIVE: This
review focused on the herbs which have been shown TG lowering effect.
METHODS: The search was done in PubMed, Science Direct, Scopus, Web of Science and Google Scholar databases a 20-year period between 1997 to 2017 with keywords search of medicinal plant, plant extract, hypertriglyceridemia, dyslipidemia, hyperlipidemia, lipoprotein lipase and apolipoprotein.
RESULTS: According to the results, many plants showed positive effects but Allium sativum, Nigella sativa, Curcuma longa, Anethum graveolens and Commiphora mukul had the best TG lowering effect with exact mechanisms of action.
CONCLUSIONS: It seems that use of these plants as complementary therapeutics or extraction of their active ingredients along with currently available drugs will improve the management of HTg in patients.