背景:下腰痛(LBP)是影响边缘系统不可或缺的身体和情绪因素的主要公共卫生问题。本研究旨在探讨随着LBP持续时间的增加,LBP与脑形态学改变之间的关系(急性与慢性)。
方法:我们使用UKBiobank数据来研究急性LBP(N=115)中边缘系统的形态特征,慢性LBP(N=243)和对照(N=358),并尝试用一个独立的数据集复制我们的研究结果,该数据集由来自OpenPain数据库的45名急性LBP参与者在1年的不同时间点进行评估。
结果:我们发现,与慢性LBP和无痛对照组相比,急性LBP与伏隔核体积增加有关,杏仁核,海马体,还有丘脑,海马和后扣带回的灰质体积增加。在复制队列中,我们发现,与1年访视(慢性LBP)相比,3个月访视(急性LBP)中的海马和丘脑体积无明显增加,具有与英国生物库数据集相似的效果大小。
结论:我们的结果表明,急性LBP与边缘系统和中脑边缘通路的形态学急剧增加有关,这可能反映了LBP早期活跃的大脑反应和自我调节。
结论:我们的研究表明,急性期的LBP与某些边缘区域的脑形态变化(增加)有关,表明LBP的急性期可能代表了自我调节和对疾病发作的积极反应的关键阶段。
BACKGROUND: Low back pain (LBP) is a major public health issue that influences physical and emotional factors integral to the limbic system. This
study aims to investigate the association between LBP and brain morphometry alterations as the duration of LBP increases (acute vs. chronic).
METHODS: We used the UK Biobank data to investigate the morphological features of the limbic system in acute LBP (N = 115), chronic LBP (N = 243) and controls (N = 358), and tried to replicate our findings with an independent dataset composed of 45 acute LBP participants evaluated at different timepoints throughout 1 year from the OpenPain database.
RESULTS: We found that in comparison with chronic LBP and pain-free controls, acute LBP was associated with increased volumes of the nucleus accumbens, amygdala, hippocampus, and thalamus, and increased grey matter volumes in the hippocampus and posterior cingulate gyrus. In the replication cohort, we found non-significantly larger hippocampus and thalamus volumes in the 3-month visit (acute LBP) compared to the 1-year visit (chronic LBP), with similar effect sizes as the UK Biobank dataset.
CONCLUSIONS: Our results suggest that acute LBP is associated with dramatic morphometric increases in the limbic system and mesolimbic pathway, which may reflect an active brain response and self-regulation in the early stage of LBP.
CONCLUSIONS: Our
study suggests that LBP in the acute phase is associated with the brain morphometric changes (increase) in some limbic areas, indicating that the acute phase of LBP may represent a crucial stage of self-regulation and active response to the disease\'s onset.