背景：大多数特发性肺纤维化（IPF）患者抱怨咳嗽。IPF相关咳嗽的特征广泛为干性或非生产性。这项研究的目的是比较早期IPF患者的慢性咳嗽与社区样本中慢性咳嗽患者的咳嗽，尤其是,在社区样本中，调查IPF中的咳嗽是否比慢性咳嗽低。
方法：IPF咳嗽人群包括46例经活检证实的患者，他们主诉慢性咳嗽。对照人群由慢性咳嗽患者组成，通过发送给公共服务雇员和芬兰养老金领取者联合会的基于社区的电子邮件调查收集。病例对照设置应用于四岁，性别,每个IPF咳嗽患者的社区样本和吸烟状况匹配的受试者。所有受试者填写咳嗽特异性生活质量问卷(莱斯特咳嗽问卷(LCQ))。LCQ问卷包含19个问题，每个问题的得分从1到7，总分从3到21，较小的值表示更严重的损害。
结果：痰产生频率，根据LCQ问题2评估,IPF慢性咳嗽人群为5.0(3.0~6.0),社区慢性咳嗽人群为5.0(3.0~6.0)(中位数和四分位距p=0.72).IPF慢性咳嗽人群的LCQ总分为14.8（11.5-18.1），社区慢性咳嗽人群的LCQ总分为15.4（13.0-17.5）（p=0.76）。领域影响得分是物理的，4.9（3.9-6.1）与5.1（4.5-5.6）（p=0.80）；心理，4.6（3.7-5.9）与4.7（3.9-5.7）（p=0.90）；和社会，5.5（3.7-6.5）vs.5.5（4.5-6.3）（p=0.84），分别。此外，对油漆或烟雾的咳嗽反应，咳嗽令人不安的睡眠，两组间每天的咳嗽频率没有差异。
结论：通过LCQ无法区分早期IPF患者的咳嗽与社区人群的慢性咳嗽。尤其是,自我报告的咳嗽相关痰液产生频率无差异.
BACKGROUND: Most patients with idiopathic pulmonary fibrosis (IPF) complain of cough. IPF-associated cough is widely characterized as dry or non-productive. The aim of this
study was to compare chronic cough in early stage IPF patients to cough in subjects with chronic cough from a community-based sample and, especially, to investigate whether cough in IPF is less productive than chronic cough in a community-based sample.
METHODS: The IPF cough population consisted of 46 biopsy-confirmed patients who complained of chronic cough. Control population consisted of subjects with chronic cough, gathered by a community-based email survey sent to public service employees and the Finnish Pensioners\' Federation. A case-control setting was applied by having four age, gender, and smoking-status matched subjects from the community sample for each IPF cough patient. A cough specific quality of life questionnaire (Leicester Cough Questionnaire (LCQ)) was filled in by all subjects. The LCQ questionnaire contains 19 questions, each question is scored from 1 to 7 and total score from 3 to 21 with a smaller value indicating more severe impairment.
RESULTS: The sputum production frequency, as assessed by LCQ question 2, was 5.0 (3.0-6.0) in the IPF chronic cough population and 5.0 (3.0-6.0) in the community-based chronic cough population (median and interquartile range p= 0.72). The LCQ total score was 14.8 (11.5-18.1) in the IPF chronic cough population and 15.4 (13.0-17.5) in the community-based chronic cough population (p=0.76). The domain impact scores were physical, 4.9 (3.9-6.1) vs. 5.1 (4.5-5.6) (p=0.80); psychological, 4.6 (3.7-5.9) vs. 4.7 (3.9-5.7) (p=0.90); and social, 5.5 (3.7-6.5) vs. 5.5 (4.5-6.3) (p=0.84), respectively. Furthermore, cough response to paint or fumes, cough disturbing sleep, and cough frequency per day did not differ between the groups.
CONCLUSIONS: Cough in early stage IPF patients was not distinguishable from chronic cough in the community-based population by LCQ. Especially, there was no difference in the self-reported frequency of cough-associated sputum production.
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