■研究不同剂量的米伐库铵的作用时间过程,并确定用于儿童日间泌尿外科手术的喉罩气道(LMA)插入的合适剂量。
■在2021年3月至2021年12月期间参加本研究的105名患者被随机分为3组:A组(mivacurium0.15mg/kg,n=35),B组(米伐库铵0.20mg/kg,n=35)和C组(米伐库铵0.25mg/kg,n=35)。在插入LMA之前注射不同剂量的米伐库铵。主要结果包括LMA插入-18评分的条件分级,发病时间,恢复指数和米伐库铵有效的持续时间。次要结果包括脉搏氧饱和度,平均血压,心率和不良事件的发生率。
■A组插入LMA的条件得分显着低于C组和B组(p<0.005)。B组和A组之间的起效时间存在显着差异(p<0.005)。两组不良反应总发生率差异无统计学意义(p>0.05)。
■使用0.2mg/kg米伐库铵麻醉可有效缩短起效时间,并有助于在接受日间泌尿外科手术的儿童中插入LMA。
UNASSIGNED: To investigate the time course of action of different doses of mivacurium and determine the appropriate dose for laryngeal mask airway (LMA) insertion for day-
case urologic surgery in children.
UNASSIGNED: A total of 105 patients who enrolled in this study between March 2021 and December 2021 were randomised into 3 groups: Group A (mivacurium 0.15 mg/kg, n = 35), Group B (mivacurium 0.20 mg/kg, n = 35) and Group C (mivacurium 0.25 mg/kg, n = 35). The different doses of mivacurium were injected before LMA insertion. The primary outcomes included the grading of conditions for the LMA insertion-18 score, onset time, recovery index and the duration that mivacurium was effective. Secondary outcomes included pulse oxygen saturation, mean blood pressure, heart rate and the incidence of adverse events.
UNASSIGNED: The score of the conditions for LMA insertion in Group A was significantly lower than in Groups C and B (p < 0.005). There was a significant difference in the onset time between Groups B and A (p < 0.005). There was no significant difference in the overall incidence of adverse reactions between these groups (p > 0.05).
UNASSIGNED: Anaesthesia with 0.2 mg/kg of mivacurium can effectively shorten the onset time and facilitate insertion of the LMA in children undergoing day-
case urologic surgery.