背景:Zatariamultiflora被用作镇咳,抗痉挛,镇痛等.传统医学中的代理人。现代医学研究也证实了这种植物通过抗炎治疗呼吸问题的效果,抗氧化和免疫调节特性。
目的:我们评估了Z.multiflora在肺功能测试中的疗效,呼吸道症状,吸入支气管扩张剂药物的使用,COPD患者的血液学因素。
方法:患者(n=45)随机分为以下三组:安慰剂组(P),组接受Z.multiflora提取物3和6mg/kg/天(Z3和Z6)。FEV1和MEF25-75,呼吸道症状,在治疗前和治疗后1-2个月评估吸入支气管扩张剂药物的使用和血液学因素。
结果:Z.多花导致FEV1显著增强(p<0.05至p<0.01)。与基线值相比,用提取物治疗1个月和2个月后,呼吸道症状也显著改善(p<0.05至p<0.001)。在接受提取物的组中,吸入支气管扩张剂药物的使用在研究结束时显著下降(两者,p<0.05)。与基线值相比,在用提取物治疗组治疗后1-2个月观察到总WBC减少(p<0.05至p<0.001)。与治疗1个月相比,Z3和Z6组的中性粒细胞在2个月后明显下降(p<0.05至p<0.01)。
结论:证据表明,这种草药对COPD患者有治疗作用,这可能是由于有助于减少炎症的特性。
BACKGROUND: Zataria multiflora is employed as an antitussive, anti-spasmodic, analgesic and etc. Agent in traditional medicine. The modern medical studies are also confirmed effects of this plant for treatment of respiratory problems via anti-inflammatory, anti-oxidant and immunomodulatory properties.
OBJECTIVE: We evaluated efficacy of Z. multiflora on tests of pulmonary function, respiratory symptoms, inhaled bronchodilator drugs use, and hematological factors in COPD patients.
METHODS: Patients (n = 45) were randomly grouped in the following three groups: placebo group (P), groups received Z. multiflora extract 3 and 6 mg/kg/day (Z3 and Z6). FEV1 and MEF25-75, respiratory symptoms, inhaled bronchodilator drugs use and hematological factors were evaluated before and 1-2 months after treatment.
RESULTS: Z. multiflora led to significant enhancement of FEV1 (p < 0.05 to p < 0.01). Respiratory symptoms were also considerably ameliorated following treatment with extracts for 1 and 2 months compared to baseline values (p < 0.05 to p < 0.001). In groups received extract, inhaled bronchodilator drugs use was remarkably declined at the end of
study (both, p < 0.05). Reduction of total WBC was observed 1-2 months after treatment in treated groups with extract compared to baseline values (p < 0.05 to p < 0.001). Neutrophils were remarkably declined in Z3 and Z6 groups after 2-monthes compared to 1-month treatment (p < 0.05 to p < 0.01).
CONCLUSIONS: The evidence show therapeutic effect of this herb on COPD patients which could be result from properties that help to decrease inflammation.