■在某些情况下,个体选择在妊娠下半年因胎儿畸形而终止妊娠。本报告提供了有关此类病例的临床管理的客观信息,并对使用米非司酮-米索前列醇的妊娠晚期流产引产结果的文献进行了系统回顾。
该研究是一个案例系列,描述了胎儿畸形引产流产的结果,在胎龄24周及以上。进行了系统审查,搜索PubMed,Embase,和Cochrane数据库。两名独立作者对文章中的数据进行了审查和质量评估。
■在两年期间,15例患者符合纳入标准。14名患者接受了米非司酮和米索前列醇,其中一人接受了催产素.全部阴道分娩。13名患者在首次服用米索前列醇24小时内分娩,一半在12小时内交付。在我们的系列中,从米索前列醇开始到胎儿排出的平均间隔为15.5小时。系统审查确定了九篇文章,所有回顾性研究。米非司酮-米索前列醇的引产方案,报告胎龄,关键的比较差异很大。
该系列病例说明主要使用米非司酮-米索前列醇联合用药成功终止妊娠。当前证据的确定性很低,基于等级框架。米非司酮-米索前列醇对妊娠晚期结局的未来研究是必要的。
UNASSIGNED: Under some circumstances, individuals choose to undergo pregnancy termination for foetal anomalies in the second half of pregnancy. This report provides objective information on the clinical management of such cases and a systematic review of the literature on labour induction outcomes for third-trimester abortion using mifepristone-misoprostol.
UNASSIGNED: The study is a
case series describing outcomes for labour induction abortion for foetal anomalies, at gestational age 24 weeks and beyond. A systematic review was performed, searching PubMed, Embase, and Cochrane databases. Two independent authors reviewed and quality assessed the data from the articles.
UNASSIGNED: During a two-year period, 15 patients met inclusion criteria. Fourteen patients received mifepristone and misoprostol, and one received oxytocin. All delivered vaginally. Thirteen patients delivered within 24 hours of the first misoprostol dose, and half delivered within 12 hours. The average interval from misoprostol initiation to foetal expulsion was 15.5 hours in our series. The systematic review identified nine articles for inclusion, all retrospective studies. Labour induction protocols for mifepristone-misoprostol, reporting of gestational age, and key comparisons varied greatly.
UNASSIGNED: The
case series illustrates successful termination of pregnancy primarily using combined mifepristone-misoprostol. Certainty of current evidence is low, based on the GRADE framework. Future research is necessary on third-trimester outcomes with mifepristone-misoprostol.