LYMPH NODES

淋巴结
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  • 文章类型: Journal Article
    Thyroid nodule and cervical lymph node biopsy is the main clinical method for evaluating the condition and determining the follow-up treatment plan. The literature on thyroid nodule puncture predominantly focuses on thyroid fine needle puncture, and there are limited systematic articles on coarse needle aspiration for thyroid-related diseases and needle biopsy of thyroid-related cervical lymph node diseases. However, this shortage of articles does not reflect the diagnostic value of coarse needle aspiration in thyroid biopsy and cervical lymph node-related diseases. Currently, different departments of many hospitals in China are conducting or planning to perform needle biopsy of thyroid and cervical lymph node-related diseases to improve the standardization and safety of related operations. Standardization is needed for the indications, contraindications, perioperative period, postoperative complications management, puncture specimen processing, and related genetic analysis of thyroid and cervical lymph node puncture. For this purpose, Interventional Ultrasound Committee of Chinese College of Interventionalists organized a panel of domestic experts in the field of thyroid diseases to discuss and formulate a consensus. Based on the latest research progress, combined with the clinical realities in China, this Expert Consensus on Ultrasound Guided Thyroid and Neck Lymph Node Puncture (2023 edition) is released.
    甲状腺结节及颈部淋巴结穿刺活检是临床中评估病情和确定后续治疗方案的主要方法。目前针对甲状腺结节穿刺的相关文献主要集中在甲状腺细针穿刺,对于甲状腺相关疾病的粗针穿刺及与甲状腺相关颈部淋巴结疾病穿刺活检的系统性指南较为缺乏,无法体现粗针穿刺在甲状腺及颈部淋巴结相关疾病中的诊断价值。现阶段,国内许多医院的不同科室都在开展或拟开展甲状腺结节及颈部淋巴结相关疾病的穿刺活检工作,为提高相关操作的规范性和安全性,需要对甲状腺结节及颈部淋巴结穿刺的适应证、禁忌证、围手术期、术后并发症处理、穿刺标本处理、相关基因分析等多方面问题进行规范。为此,中国医师协会介入医师分会超声介入专业委员会组织国内部分甲状腺疾病相关领域的专家,依据最新研究进展并结合我国临床实际情况讨论并制定本共识,现予以发布。.
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  • 文章类型: Journal Article
    背景:食管鳞状细胞癌是中国最常见的癌症之一,术后放疗对改善患者预后有重要作用。食管不同部位的癌在手术后可能有不同的淋巴结转移模式。
    方法:在这项多中心回顾性研究中,我们纳入了3个癌症中心的中胸食管鳞状细胞癌患者,手术前后均未接受放疗。我们分析了不同站点的淋巴结复发率,以探讨术后淋巴复发的方式。
    结果:从1月1日起,2014年12月31日,2019年,132名患者符合标准,并纳入本研究。淋巴复发率为62.1%。病理分期(P=0.032)和淋巴结清扫方式(P=0.006)是预测淋巴结复发的重要因素。锁骨上的复发率,上、下气管旁淋巴结站占32.6%,28.8%和16.7%,分别,显示高发病率。隆突下淋巴结站的复发率为9.8%,而8.3%(上,中段和下段)胸段食管旁淋巴结复发。
    结论:我们建议包括锁骨上,胸中食管癌术后放射视野中淋巴结的上、下气管旁位置。隆隆师站也有潜在的高风险,而是否包括胸段食管旁或腹部结节需要仔细考虑。
    BACKGROUND: Oesophageal squamous cell carcinoma is one of the most commonly diagnosed carcinomas in China, and postoperative radiotherapy plays an important role in improving the prognosis of patients. Carcinomas in different locations of the oesophagus could have different patterns of lymph node metastasis after surgery.
    METHODS: In this multicentric retrospective study, we enrolled patients with middle thoracic oesophageal squamous cell carcinomas from 3 cancer centres, and none of the patients underwent radiotherapy before or after surgery. We analysed the lymph node recurrence rates in different stations to explore the postoperative lymphatic recurrence pattern.
    RESULTS: From January 1st, 2014, to December 31st, 2019, 132 patients met the criteria, and were included in this study. The lymphatic recurrence rate was 62.1%. Pathological stage (P = 0.032) and lymphadenectomy method (P = 0.006) were significant predictive factors of lymph node recurrence. The recurrence rates in the supraclavicular, upper and lower paratracheal stations of lymph nodes were 32.6%, 28.8% and 16.7%, respectively, showing a high incidence. The recurrence rate of the subcarinal node station was 9.8%, while 8.3% (upper, middle and lower) thoracic para-oesophageal nodes had recurrences.
    CONCLUSIONS: We recommend including the supraclavicular, upper and lower paratracheal stations of lymph nodes in the postoperative radiation field in middle thoracic oesophageal carcinomas. Subcarinal station is also potentially high-risk, while whether to include thoracic para-oesophageal or abdominal nodes needs careful consideration.
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  • 文章类型: Journal Article
    目的:研究基于前列腺特异性膜抗原-正电子发射断层扫描(Ga68PSMA-PETCT)的高危(HR)前列腺癌单纯前列腺放疗(PORT)后生化衰竭(BCF)复发模式及其对盆腔轮廓检查建议的影响。
    方法:接受根治性PORT和雄激素剥夺治疗(ADT)的临床放射学高危淋巴结阴性前列腺癌患者,在POP-RT随机试验或非试验中,纳入了在BCF后接受Ga68PSMA-PETCT的患者。研究了Ga68PSMA-PETCT的区域和远处复发模式。参照耻骨联合的上边界绘制了盆腔淋巴结复发图。已发布的轮廓指南中的盆腔淋巴结尾边界(PLNcb)建议(RTOGcb,GETUGcb,PIVOTALcb,NRGcb,GFRUcb)进行了评估。
    结果:在筛查的262名患者中,纳入68例符合条件的患者(POP-RT试验35例;试验外33例)。中位随访时间为91个月(IQR,72-117),BCF的中位时间为65个月(IQR,49-83).31例(46%)和31例(46%)患者出现区域性和远处复发,分别。在淋巴结复发中,近一半(46%,14/31)无远处转移,64%(20/31)的髂总结区失败。最低的淋巴结复发是颅骨至耻骨联合顶部20毫米(RTOGcb,GETUGcb,GFRUcb)和头颅10毫米。NRG指南推荐的PLNcb(NRGcb)的患者间变异性为32mm,耻骨联合顶部从16毫米以上到16毫米以下,最低的淋巴结复发范围从4毫米到36毫米颅至NRGcb。
    结论:盆腔衰竭占单纯前列腺放疗后复发的主要比例,尾部大部分结节复发为颅骨至耻骨联合顶部20毫米。这可能对定义轮廓建议的尾边界产生影响。
    OBJECTIVE: To study prostate specific membrane antigen - positron emission tomography (Ga68PSMA-PETCT) based patterns of relapse at biochemical failure (BCF) after prostate-only radiotherapy (PORT) in high-risk (HR) prostate cancer and its implications on pelvic contouring recommendations.
    METHODS: Patients with clinico-radiological high-risk node-negative prostate cancer treated with curative PORT and androgen deprivation therapy (ADT), either within the POP-RT randomised trial or off trial, who underwent a Ga68PSMA-PETCT upon BCF were included. Patterns of regional and distant recurrence on Ga68PSMA-PETCT were studied. Pelvic nodal recurrences were mapped with reference to the superior border of pubic symphysis. Pelvic lymph nodal caudal border (PLNcb) recommendations in the published contouring guidelines (RTOGcb, GETUGcb, PIVOTALcb, NRGcb, GFRUcb) were evaluated.
    RESULTS: Of the total 262 patients screened, 68 eligible patients were included (POP-RT trial 35 patients; off-trial 33 patients). Median follow-up was 91 months (IQR, 72-117) and median time to BCF was 65 months (IQR, 49-83). Regional and distant recurrence was seen in 31 (46%) and 31 (46%) patients, respectively. Of the nodal recurrences, nearly half (46%, 14/31) had no distant metastases and 64% (20/31) had a failure in the common iliac nodal region. The lower-most nodal recurrence was 20 mm cranial to the top of pubic symphysis (RTOGcb, GETUGcb, GFRUcb) and 10 mm cranial to the PIVOTALcb. The PLNcb recommended by NRG guideline (NRGcb) had an inter-patient variability of 32 mm, ranging from 16 mm above to 16 mm below the top of pubic symphysis, and the lower most nodal recurrence ranged from 4 mm to 36 mm cranial to NRGcb.
    CONCLUSIONS: Pelvic failures accounted for a major proportion of recurrences after prostate-only radiotherapy, with the caudal most nodal recurrence being 20 mm cranial to the top of pubic symphysis. This could have implications in defining the caudal border of contouring recommendations.
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  • 文章类型: Journal Article
    目的:本研究的目的是就宫颈癌前哨淋巴结(SLN)清扫的手术技术达成共识。
    方法:一项26个问题的调查通过电子邮件发送给国际妇科肿瘤外科专家。采用两步改进的德尔菲法建立共识。经过第一轮在线调查,问题被修改,第二轮,进行了半结构化访谈。共识是使用70%的协议截止来定义的。
    结果:38位专家中有25位(65.8%)对第一轮和第二轮在线调查做出了回应。在第一轮中,有13个(50.0%)问题达成了≥70%的协议,在最后一轮中达成了15个(57.7%)的协议。共识协议确定了15个建议,三个可选,5个不推荐的步骤专家同意以下推荐的程序:使用吲哚菁绿作为示踪剂;在3点和9点进行表面(有或没有深度)注射;在未受累的粘膜边缘注射,避免阴道孔;用镊子抓住子宫颈,仅在子宫颈的一部分没有肿瘤;在简单的行囊/锥形切开术的情况下,使用微创方法进行SLN活检;识别输尿管切除术,脐动脉闭塞,SLN切除前和髂外血管;在子宫动脉水平开始解剖并横向继续;在进入对侧之前完成一个半骨盆的解剖。在建议6点和12点不注射方面也达成了共识,并在肿瘤完全替代子宫颈的情况下直接注射到肿瘤中;防止在没有保护性操作的情况下通过端口去除节点;没有超稳定方案;并防止在标测失败后重新注射时改变示踪剂浓度。
    结论:推荐,可选,根据国际专家的共识,确定了不推荐的宫颈癌SLN解剖步骤。这些代表了外科指南,可供外科医生在临床试验中使用,并在常规实践中用于质量保证。
    OBJECTIVE: The purpose of this study was to establish a consensus on the surgical technique for sentinel lymph node (SLN) dissection in cervical cancer.
    METHODS: A 26 question survey was emailed to international expert gynecological oncology surgeons. A two-step modified Delphi method was used to establish consensus. After a first round of online survey, the questions were amended and a second round, along with semistructured interviews was performed. Consensus was defined using a 70% cut-off for agreement.
    RESULTS: Twenty-five of 38 (65.8%) experts responded to the first and second rounds of the online survey. Agreement ≥70% was reached for 13 (50.0%) questions in the first round and for 15 (57.7%) in the final round. Consensus agreement identified 15 recommended, three optional, and five not recommended steps. Experts agreed on the following recommended procedures: use of indocyanine green as a tracer; superficial (with or without deep) injection at 3 and 9 o\'clock; injection at the margins of uninvolved mucosa avoiding vaginal fornices; grasping the cervix with forceps only in part of the cervix is free of tumor; use of a minimally invasive approach for SLN biopsy in the case of simple trachelectomy/conization; identification of the ureter, obliterated umbilical artery, and external iliac vessels before SLN excision; commencing the dissection at the level of the uterine artery and continuing laterally; and completing dissection in one hemi-pelvis before proceeding to the contralateral side. Consensus was also reached in recommending against injection at 6 and 12 o\'clock, and injection directly into the tumor in cases of the tumor completely replacing the cervix; against removal of nodes through port without protective maneuvers; absence of an ultrastaging protocol; and against modifying tracer concentration at the time of re-injection after mapping failure.
    CONCLUSIONS: Recommended, optional, and not recommended steps of SLN dissection in cervical cancer have been identified based on consensus among international experts. These represent a surgical guide that may be used by surgeons in clinical trials and for quality assurance in routine practice.
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  • 文章类型: English Abstract
    Multiple ground glass nodules (GGN) like lung cancer is a special type of synchronous multiple primary lung cancer, with two or more lesions present simultaneously. It has characteristics such as\"indolent\"development, less lymph node or distant metastasis, identical or different pathological stages, differential driving gene mutations, diverse imaging manifestations, and good prognosis. In order to standardize the diagnosis and treatment behavior of multiple GGN-like lung cancer, reduce issues such as over diagnosis and insufficient treatment, relevant domestic experts are organized by The Lung Cancer Medical Education Committee of the Chinese Medical Education Association, Lung Cancer Alliance of Chinese Thoracic Surgery, the Society of Tumor Ablation Therapy of the Chinese Anti-Cancer Association, the Tumor Ablation Expert Committee of the Chinese Society of Clinical Oncology, the Tumor Ablation Expert Group of the Chinese College of Interventionalists, The Chinese Expert Consensus:Multidisciplinary Diagnosis and Treatment of Multiple Ground-Glass Nodule Like Lung Cancer (2024 Edition) was discussed and formulated. The main content includes: follow-up strategies, differential diagnosis, diagnosis and staging, treatment methods, and post treatment follow-up for multiple GGN-like lung cancer.
    多发磨玻璃结节(GGN)样肺癌是同时性多原发肺癌的一种特殊类型,同时存在2个及2个以上病灶,具有“惰性”发展、极少淋巴结或远处转移、病理阶段相同或不同、驱动基因突变具有差异性、影像学表现多样化和预后较好等特点。为规范多发GGN样肺癌的诊疗行为,降低过度诊治和诊治不足等问题,由中国医药教育协会肺癌医学教育委员会、中国胸外科肺癌联盟、中国抗癌协会肿瘤消融治疗专业委员会、中国临床肿瘤学会(CSCO)肿瘤消融专家委员会、中国医师协会介入医师分会肿瘤消融专家工作组组织国内有关专家,讨论制订了《多发磨玻璃结节样肺癌多学科诊疗中国专家共识(2024年版)》。主要内容包括:多发GGN样肺癌的随访策略、鉴别诊断、诊断与分期、治疗手段和治疗后随访。.
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  • 文章类型: English Abstract
    Penile squamous cell carcinoma is a rare, highly aggressive cancer of older men. The metastatic stage has significant therapeutic and prognostic features. Treatment of penile cancer is significantly influenced by the operation, in which an R0 situation must be achieved to ensure a realistic chance of cure. Other local therapeutic procedures such as radiotherapy are often of secondary importance. Neoadjuvant and adjuvant chemotherapy are relevant components of multimodal therapy. Post-therapeutically, patients require lifelong, risk-adapted follow-up care.
    UNASSIGNED: Das Plattenepithelkarzinom des Penis ist eine seltene hochaggressive Krebserkrankung des älteren Mannes. Das metastasierte Stadium hat entscheidende therapeutische und prognostische Besonderheiten. Die Therapie des Peniskarzinoms wird maßgeblich von der Operation geprägt, die im Gesunden erfolgen muss, um eine realistische Heilungschance zu gewährleisten. Andere lokaltherapeutische Verfahren wie Strahlentherapie sind häufig nur nachrangig. Neoadjuvante und adjuvante Chemotherapien sind relevante Bestandteile der multimodalen Therapie im metastasierten Stadium. Posttherapeutisch bedürfen die Patienten einer lebenslangen, risikoadaptierten Nachsorge.
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  • 文章类型: English Abstract
    Lateral lymph node metastasis (LLNM) is common in mid-low rectal cancer and is also a major cause of postoperative local recurrence. Currently, there is still controversy regarding the diagnosis and treatment of LLNM in rectal cancer. This consensus, based on the \"Chinese Consensus on Diagnosis and Treatment of Lateral Lymph Node Metastasis in Rectal Cancer (2019 edition),\" incorporates the latest domestic and international research findings and revises aspects related to the diagnosis, treatment strategies, follow-up, and management of recurrence of LLNM in rectal cancer. A total of 42 domestic colorectal cancer experts participated in this consensus. It proposes 18 consensus statements on the diagnosis and treatment of LLNM, using the evaluation criteria of the U.S. Preventive Services Task Force for grading recommendations. The aim is to standardize further the diagnostic criteria and treatment strategies for LLNM in rectal cancer. Unresolved issues in this consensus require further clinical practice and active engagement in high-quality clinical research to explore and address them progressively.
    侧方淋巴结是中低位直肠癌常见的转移部位,亦是术后局部复发的主要原因。目前国际上针对直肠癌侧方转移的诊断、治疗尚存争议。本共识在《中国直肠癌侧方淋巴结转移诊疗共识(2019版)》的基础上,结合国内外最新研究成果,国内42位结直肠癌研究领域的专家针对直肠癌侧方淋巴结转移的诊断、治疗策略、随诊以及复发处理4个方面进行修订,提出18条侧方淋巴结诊疗相关共识,并采用美国预防医学工作组的评价标准进行等级推荐,旨在进一步规范直肠癌侧方淋巴结转移的诊断标准及治疗策略。在本共识中未解决的相关问题,尚需进一步临床实践,并积极开展高质量的临床研究逐步探索和解决。.
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  • 文章类型: Journal Article
    韩国妇科肿瘤学会(KSGO)一直在努力通过制定2021年更新的临床实践指南来标准化和提高国内子宫体癌治疗的质量。KSGO根据文献检索使用4个关键要素修订了指南:人口,干预,比较,结果框架。这些要素包括评估免疫检查点抑制剂治疗在铂类化疗失败的复发/晚期子宫内膜癌患者中的疗效和安全性。以及曲妥珠单抗联合治疗HER2/neu阳性子宫内膜癌患者的效果。此外,该指南评估了低风险子宫内膜癌患者省略淋巴结清扫术的有效性和安全性,探讨前哨淋巴结定位在早期子宫内膜癌手术中的作用,讨论了化疗作为晚期(III-IVA期)子宫内膜癌患者术后治疗的结果,探讨免疫检查点抑制剂初始治疗对晚期或复发子宫内膜癌患者生存率的影响。
    The Korean Society of Gynecologic Oncology (KSGO) had been making an effort to standardize and enhance the quality of domestic uterine corpus cancer treatment by developing updated clinical practice guidelines in 2021. The KSGO revised the guidelines based on a literature search using 4 key elements: Population, Intervention, Comparison, and Outcome framework. These elements include the evaluation of the efficacy and safety of immune checkpoint inhibitor treatment in recurrent/advanced endometrial cancer patients who have failed platinum-based chemotherapy, as well as the effect of combined treatment with trastuzumab in patients with HER2/neu-positive endometrial cancer. Additionally, the guideline assessed the efficacy and safety of omitting lymph node dissection in low-risk endometrial cancer patients, investigated the effect of sentinel lymph node mapping in early-stage endometrial cancer surgery, addressed the outcome of chemoradiation therapy as a postoperative treatment in patients with advanced (stage III-IVA) endometrial cancer, and explored the impact of initial treatment with immune checkpoint inhibitors on survival in patients with advanced or recurrent endometrial cancer patients.
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