目标:目前,在新的精神活性物质中,卡西酮衍生物构成了最大的群体,主要分为N-烷基化,3,4-亚甲基二氧基-N-烷基化,N-吡咯烷基,和3,4-亚甲基二氧基-N-吡咯烷基衍生物。这些衍生物正在积极地在烷基链或芳香环上进行微小的修饰,以产生新的合成卡辛酮,其目的是规避法律。在这次审查中,重点介绍了2014-2017年期间出现在非法药物市场上的新合成卡西酮,并通过气相色谱-质谱和液相色谱-串联质谱对其进行了表征。
方法:使用各种关键词在多个数据库中进行广泛的文献检索,特别适用于2014年至2017年间出现的合成卡西酮。
结果:发现了30多种新的卡西酮衍生物。还引用了新衍生物的先前存在的母体化合物,他们的质谱数据被汇编在一个表格中,以便于法医毒理学家鉴定他们。
结论:据我们所知,这是最新的评论提出了新的合成卡西酮。政治当局应采取措施实施和执行通用计划(综合系统)法律,以控制各种修饰的合成卡西诺酮。用新发现补充现有数据库可以极大地促进法医毒理学家的努力。
OBJECTIVE: Currently, among new psychoactive substances, cathinone derivatives constitute the biggest group, which are mainly classified into N-alkylated, 3,4-methylenedioxy-N-alkylated, N-pyrrolidinyl, and 3,4-methylenedioxy-N-pyrrolidinyl derivatives. These derivatives are actively being subjected to minor modifications at the alkyl chains or the aromatic ring to create new synthetic cathinones with the goal of circumventing laws. In this
review, the new synthetic cathinones that have appeared on the illegal drug market during the period 2014-2017 are highlighted, and their characterization by gas chromatography-mass spectrometry and liquid chromatography-tandem mass spectrometry is presented.
METHODS: Various key words were used to conduct an extensive literature search across a number of databases, specifically for synthetic cathinones that emerged between 2014 and 2017.
RESULTS: More than 30 new cathinone derivatives were discovered. The preexisting parental compounds for the new derivatives are also referenced, and their mass spectral data are compiled in a table to facilitate their identification by forensic toxicologists.
CONCLUSIONS: To our knowledge, this is the most current
review presenting new synthetic cathinones. Political authorities should take measures to implement and enforce generic scheduling (comprehensive system) laws to control the diversely modified synthetic cathinones. Supplementing the existing databases with new findings can greatly facilitate the efforts of forensic toxicologists.