■川崎病(KD)是一种以全身性小血管炎为特征的儿科血管疾病,尤其是冠状动脉炎,发病机制不清楚。这项探索性病例对照研究调查了叶酸(FA)、维生素D3(VD3),和维生素B12(VB12)水平和不同类型的川崎病,以及冠状动脉病变(CAL)的发生率。
■在这项探索性病例对照研究中,从2022年1月1日至2023年6月30日入住我们医院的365名KD儿童被纳入KD组。同时,以同期接受体检的健康儿童365例为对照组。KD组分为典型KD组和不完全KD组(IKD组),CALS组和非CALS组,IVIG敏感组和IVIG耐药组。将CAL患儿分为小肿瘤组,中肿瘤组和大肿瘤组。血清FA水平,比较所有组的VB12和VD3。
■KD组和CAL组的血清FA和VD3水平均显着降低(p<0.05),这两个因素均被确定为KD和CAL的独立危险因素。同样,在IKD和IVIG耐药组中观察到血清VD3水平降低(p<0.05),VD3也是IKD和IVIG耐药的独立危险因素。此外,在大动脉瘤组血清FA水平较低(p<0.05),确定FA是动脉瘤大小的独立危险因素。
■KD患儿血清叶酸FA和维生素VD3水平显著降低。此外,这些减少在IKD和CAL患儿中更为明显.这种模式表明,较低的FA和VD3水平可能会增加KD患者发生更严重冠状动脉病变的风险。因此,监测这些生物标志物可以为早期临床诊断和干预提供有价值的见解.
UNASSIGNED: Kawasaki Disease (KD) is a pediatric vasculitic disorder characterized by systemic small vasculitis, notably coronary arteritis, with unclear pathogenesis. This explorative
case-control study investigated the association between folic acid (FA), vitamin D3 (VD3), and vitamin B12 (VB12) levels and the different types of Kawasaki Disease, as well as the incidence of coronary artery lesions (CALs).
UNASSIGNED: In this explorative
case control study, 365 KD children admitted to our hospital from January 1, 2022 to June 30, 2023 were included as the KD group. Simultaneously, 365 healthy children who received physical examination during the same period were included as the control group. The KD group was divided into typical KD group and incomplete KD group (IKD group), CALs group and non-CALS group, and IVIG sensitive group and IVIG resistant group. The children with CALs were divided into small tumor group, medium tumor group and large tumor group. Serum levels of FA, VB12, and VD3 were compared across all groups.
UNASSIGNED: Serum levels of FA and VD3 were significantly decreased in both the KD and CALs groups (p < 0.05), and both factors were identified as independent risk factors for KD and CALs. Similarly, reduced serum VD3 levels were observed in the IKD and IVIG-resistant groups (p < 0.05), with VD3 also being an independent risk factor for both IKD and IVIG resistance. Additionally, lower serum FA levels were noted in the group with large aneurysms (p < 0.05), establishing FA as an independent risk factor for aneurysm size.
UNASSIGNED: Serum levels of folic FA and vitamin VD3 were significantly reduced in children with KD. Furthermore, these reductions were more pronounced in children with IKD and CALs. This pattern suggests that lower FA and VD3 levels may increase the risk of more severe coronary lesions in KD patients. Therefore, monitoring these biomarkers could provide valuable insights for early clinical diagnosis and intervention.