目的:癌症患者对医疗服务的利用和费用通常通过护理阶段来估计:最初,临时,或终端。尽管它们的持续时间通常是任意设置的,我们试图在晚期黑色素瘤人群中使用联合点回归建立数据驱动的治疗阶段作为一个案例.
方法:进行了一项回顾性索赔数据库研究,以评估2010年1月至2014年9月期间晚期黑色素瘤从远处转移诊断到死亡的成本。联合点回归分析用于确定最佳拟合点,其中每月平均成本趋势发生了统计上的显著变化。为了确定初始阶段,对从转移诊断到死亡的平均每月费用进行建模;并对终末期从死亡到转移诊断的平均每月费用进行建模.每月成本趋势拐点表示终点和起点。这两个月之间是过渡阶段。
结果:共有1,671例晚期黑色素瘤患者死亡符合资格标准。初始阶段被确定为从诊断转移开始的5个月期,之后有一个尖锐的,每月成本趋势显着下降(每月百分比变化[MPC]=-13.0%;95%CI=-16.9%至-8.8%)。终末期定义为死亡前5个月(MPC=-14.0%;95%CI=-17.6%至-10.2%)。
结论:基于索赔的算法可能会由于错误分类而低估患者,并且可能会高估终末期成本,因为医院和急诊就诊被用作死亡指标。此外,最近批准的疗法不包括在内,这可能低估了晚期黑色素瘤的成本。
结论:在这个晚期黑色素瘤人群中,治疗初期和终末期的最佳持续时间为诊断出转移后和死亡前的5个月,分别。Joinpoint回归可用于提供数据支持的癌症护理持续时间阶段,但应结合临床判断。
OBJECTIVE: The utilization of healthcare services and costs among patients with cancer is often estimated by the phase of care: initial, interim, or terminal. Although their durations are often set arbitrarily, we sought to establish data-driven phases of care using joinpoint regression in an advanced melanoma population as a
case example.
METHODS: A retrospective claims database study was conducted to assess the costs of advanced melanoma from distant metastasis diagnosis to death during January 2010-September 2014. Joinpoint regression analysis was applied to identify the best-fitting points, where statistically significant changes in the trend of average monthly costs occurred. To identify the initial phase, average monthly costs were modeled from metastasis diagnosis to death; and were modeled backward from death to metastasis diagnosis for the terminal phase. Points of monthly cost trend inflection denoted ending and starting points. The months between represented the interim phase.
RESULTS: A total of 1,671 patients with advanced melanoma who died met the eligibility criteria. Initial phase was identified as the 5-month period starting with diagnosis of metastasis, after which there was a sharp, significant decline in monthly cost trend (monthly percent change [MPC] = -13.0%; 95% CI = -16.9% to -8.8%). Terminal phase was defined as the 5-month period before death (MPC = -14.0%; 95% CI = -17.6% to -10.2%).
CONCLUSIONS: The claims-based algorithm may under-estimate patients due to misclassifications, and may over-estimate terminal phase costs because hospital and emergency visits were used as a death proxy. Also, recently approved therapies were not included, which may under-estimate advanced melanoma costs.
CONCLUSIONS: In this advanced melanoma population, optimal duration of the initial and terminal phases of care was 5 months immediately after diagnosis of metastasis and before death, respectively. Joinpoint regression can be used to provide data-supported phase of cancer care durations, but should be combined with clinical judgement.