锯齿状息肉综合征(SPS),一种以多发性锯齿状息肉为特征的结直肠息肉病,与结直肠癌(CRC)的高风险相关。本研究旨在阐明日本SPS的临床病理特征。
我们调查了结直肠锯齿状息肉病综合征(SPS)研究组的“SPS临床病理特征多中心研究(UMIN000032138)”中SPS患者的临床病理特征。在这项研究中,根据2019年世界卫生组织(WHO)SPS诊断标准,患者被诊断为SPS.
2001年1月至2017年12月期间,在10个机构中有94名患者被诊断为SPS。每位患者切除的病变的平均数(±标准偏差[SD])为11.3±13.8。诊断SPS的平均年龄为63.3±11.6岁,58例(61.7%)为男性。87例(92.6%)和16例(17.0%)患者满足WHO诊断标准I和II,分别。9名患者(9.6%)同时满足标准I和II。在21例患者(22.3%)和24个病灶中观察到癌(T1-T4)。在21例CRC患者中,19(90.4%)满足诊断标准I,1(4.8%)满足诊断标准II,1名(4.8%)符合诊断标准I和II。在符合诊断标准I的患者中,CRC的患病率没有显着差异。II,还有我和II.
SPS患者发生CRC的风险较高,应定期进行结肠镜检查。提高对这种综合症的认识至关重要。
Serrated polyposis syndrome (SPS), a type of colorectal polyposis characterized by multiple serrated polyps, is associated with a high risk of colorectal carcinoma (CRC). This
study aimed to clarify the clinicopathological characteristics of SPS in Japan.
We investigated the clinicopathological characteristics of patients with SPS from the \"Multicenter
Study on Clinicopathological Characteristics of SPS (UMIN 000032138)\" by the Colorectal Serrated Polyposis Syndrome (SPS)
Study Group. In this
study, patients were diagnosed with SPS based on the 2019 World Health Organization (WHO) SPS diagnostic criteria.
Ninety-four patients were diagnosed with SPS in 10 institutions between January 2001 and December 2017. The mean number (± standard deviation [SD]) of resected lesions per patient was 11.3 ± 13.8. The mean age at diagnosis of SPS was 63.3 ± 11.6 years, and 58 patients (61.7%) were male. Eighty-seven (92.6%) and 16 (17.0%) patients satisfied WHO diagnostic criteria I and II, respectively. Nine patients (9.6%) satisfied both criteria I and II. Carcinoma (T1-T4) were observed in 21 patients (22.3%) and 24 lesions. Of the 21 patients with CRC, 19 (90.4%) satisfied diagnostic criterion I, 1 (4.8%) satisfied diagnostic criterion II, and 1 (4.8%) satisfied diagnostic criteria I and II. There was no notable difference in the prevalence of CRC among patients who met diagnostic criterion I, II, and both I and II.
Patients with SPS have a high risk of CRC and should undergo regular surveillance colonoscopy. Raising awareness of this syndrome is crucial.