类风湿性关节炎(RA)是一种自身免疫性系统性疾病,在其发病机制中参与多种促炎细胞因子,包括Th17细胞产生的细胞。我们进行了系统评价,旨在评估Th17细胞因子多态性之间的关联。即IL-17A,IL-17F,IL-21和IL-22与RA易感性。
我们搜索了三个电子数据库(MEDLINE,Scopus和WebofScience)用于评估RA易感性(或其临床表现)与细胞因子IL-17A多态性之间的关联的观察性研究,IL-17F,IL-21和IL-22。从选定的研究中,我们提取了有关所研究多态性的信息,评估结果,和参与者的人口特征。我们进行了随机效应荟萃分析,评估了对RA的易感性与IL-17Ars2275913,IL-17Frs763780和IL-17Frs2397084多态性的不同基因型之间的关联。使用Q-Genie工具评估主要研究的质量。
本系统综述包括15项研究。据报道,有5种IL-17A多态性与RA易感性相关。对于IL-17Ars2275913多态性,我们的荟萃分析显示AA基因型与RA的低易感性显著相关(OR=0.76;95CI=0.61-0.93;p=0.01),而GG基因型则相反(OR=1.20;95CI=1.06-1.35;p=0.01)。关于IL-17Frs763780多态性,在RA患者中发现TT基因型明显较低(OR=0.49;95CI=0.31-0.77;p=0.002),而CT基因型则相反(OR=2.00;95CI=1.03-3.87;p=0.04)。没有发现关于rs2397084多态性的显著关联。对于IL-21,rs6822844和rs4505848被描述为与RA的易感性具有显著关联。没有发现评估RA中IL-22多态性的研究。
IL-17Ars2275913和IL-17Frs763780多态性与RA的易感性以及该疾病的不同临床特征显着相关。
Rheumatoid Arthritis (RA) is an autoimmune systemic disease and in its pathogenesis participate several proinflammatory cytokines, including those produced by Th17 cells. We performed a systematic
review aiming to assess the associations between polymorphisms in Th17 cytokines, namely IL-17A, IL-17F, IL-21 and IL-22, and susceptibility to RA.
We searched three electronic databases (MEDLINE, Scopus and Web of Science) for observational studies assessing the association between susceptibility to RA (or its clinical presentation) and polymorphisms of the cytokines IL-17A, IL-17F, IL-21 and IL-22. From the selected studies, we extracted information on the studied polymorphisms, assessed outcomes, and demographic characteristics of participants. We performed random effects meta-analyses assessing the associations between susceptibility to RA and different genotypes of the IL-17A rs2275913, IL-17Frs763780 andIL-17Frs2397084polymorphisms. Primary studies\' quality was assessed using the Q-Genie tool.
Fifteen studies were included in this systematic
review. Five IL-17A polymorphisms were reported to be associated with susceptibility to RA. For the IL-17A rs2275913 polymorphism, our meta-analysis showed the AA genotype to be significantly associated with lower susceptibility to RA(OR = 0.76; 95%CI = 0.61-0.93;p = 0.01), while the opposite was observed for the GG genotype (OR = 1.20; 95%CI = 1.06-1.35;p = 0.01). Concerning IL-17Frs763780 polymorphism, theTT genotype was found to be significantly less frequent in RA patients(OR = 0.49; 95%CI = 0.31-0.77;p = 0.002), while the opposite was observed for the CT genotype (OR = 2.00; 95%CI = 1.03-3.87;p = 0.04). No significant associations were found regarding rs2397084polymorphisms. For IL-21, rs6822844 and rs4505848 were described to have significant associations with susceptibility to RA. No studies were found assessing IL-22 polymorphisms in RA.
IL-17A rs2275913 and IL-17F rs763780 polymorphisms are significantly associated with susceptibility to RA and with different clinical characteristics of this disease.