2型糖尿病(T2DM)与几种神经退行性疾病和精神疾病有关。要么是合并症,要么是风险因素。我们旨在通过检查与广泛的脑部疾病(精神和神经系统疾病,不包括迟发性神经退行性疾病),同时也考虑了T2DM和这些脑疾病的时间顺序。
在一项针对1,883,198名丹麦公民的基于人群的队列研究中,我们出生于1955-1984年,随访至2016年底,我们估计了2型糖尿病和16种在儿童和成年中期首次诊断的脑部疾病之间的关联.我们在时间排序分析(T2DM后的脑部疾病诊断,反之亦然)中,以95%置信区间(CI)计算比值比(OR)和风险比(HR)。适应性,年龄,后续行动,出生年份,和父母因素。
总共67,660名(3.6%)的研究人群在30岁和平均年龄45岁(SD为8岁)后被确定为T2DM病例。T2DM与大多数精神疾病相关。与其他(即非厌食)进食障碍(OR[95%CI]:2.64[2.36-2.94])和精神分裂症谱系障碍(2.73[2.63-2.84])的相关性最强。在神经系统疾病中,尤其是炎症性脑疾病(1.73[1.57-1.91])和癫痫(1.67[1.60-1.75])与T2DM相关。在时间排序的分析中,大多数关联都保持在两个方向上。对于大多数精神疾病,女性的联想最强。
T2DM与几种精神和神经系统疾病有关,并且对于两种时间顺序的疾病都一致发现了大多数关联。这表明T2DM和那些脑疾病的共同病因。这项研究可以成为进一步阐明疾病与共同生物学机制之间潜在因果关系的研究的起点。
Type 2 diabetes mellitus (T2DM) is linked with several neurodegenerative and psychiatric disorders, either as a comorbid condition or as a risk factor. We aimed to expand the evidence by examining associations with a broad range of brain disorders (psychiatric and neurological disorders, excluding late-onset neurodegenerative disorders), while also accounting for the temporal order of T2DM and these brain disorders.
In a population-based cohort-
study of 1,883,198 Danish citizens, born 1955-1984 and followed until end of 2016, we estimated associations between T2DM and 16 brain disorders first diagnosed between childhood and mid-adulthood. We calculated odds ratios (OR) and hazard ratios (HR) with 95% confidence intervals (CI) in temporally ordered analyses (brain disorder diagnosis after T2DM and vice versa), adjusted for sex, age, follow-up, birth year, and parental factors.
A total of 67,660 (3.6%) of the
study population were identified as T2DM cases after age 30 and by a mean age of 45 years (SD of 8 years). T2DM was associated with most psychiatric disorders. Strongest associations were seen with other (i.e. non-anorectic) eating disorders (OR [95% CI]: 2.64 [2.36-2.94]) and schizophrenia spectrum disorder (2.73 [2.63-2.84]). Among neurological disorders especially inflammatory brain diseases (1.73 [1.57-1.91]) and epilepsy (1.67 [1.60-1.75]) were associated with T2DM. Most associations remained in both directions in the temporally ordered analyses. For most psychiatric disorders, associations were strongest in females.
T2DM was associated with several psychiatric and neurological disorders, and most associations were consistently found for both temporal order of disorders. This suggests a shared etiology of T2DM and those brain disorders. This
study can form the starting point for studies directed at further elucidating potential causal links between disorders and shared biological mechanisms.