目的:评价中性粒细胞作为宿主免疫防御的第一线在小鼠牙周微环境中的调节作用。
方法:使用PubMed进行了系统搜索,WebofScience,以及2012年至2023年发表的文章的ScienceDirect数据库。在这次审查中,选择研究中性粒细胞对牙周炎小鼠模型牙槽骨吸收影响的文章,并根据合格标准进行评估。分析了可能影响结果的重要变量。
结果:本系统综述包括11篇文章。结果表明,由于它们的免疫防御功能,局部中性粒细胞的功能稳态对牙周健康至关重要。中性粒细胞缺乏加重牙槽骨丢失。然而,多项研究表明,中性粒细胞过度浸润与小鼠牙周炎引起的牙槽骨吸收呈正相关。因此,牙周炎的治疗需要考虑中性粒细胞功能的稳态。
结论:汇集分析表明,中性粒细胞在小鼠牙周炎模型的牙周组织改建中起着双向作用。因此,局部中性粒细胞功能的靶向调控为牙周炎的治疗提供了新的策略。
To evaluate the regulatory role of neutrophils as the first line of host immune defense in the periodontal microenvironment of mice.
A systematic search was performed using PubMed, Web of Science, and ScienceDirect databases for articles published between 2012 and 2023. In this
review, articles investigating the effect of neutrophils on alveolar bone resorption in a mouse model of periodontitis were selected and evaluated according to eligibility criteria. Important variables that may influence outcomes were analyzed.
Eleven articles were included in this systematic
review. The results showed that because of their immune defense functions, the functional homeostasis of local neutrophils is critical for periodontal health. Neutrophil deficiency aggravates alveolar bone loss. However, several studies have shown that excessive neutrophil infiltration is positively correlated with alveolar bone resorption caused by periodontitis in mice. Therefore, the homeostasis of neutrophil function needs to be considered in the treatment of periodontitis.
Pooled analysis suggests that neutrophils play a bidirectional role in periodontal tissue remodeling in mouse periodontitis models. Therefore, targeted regulation of local neutrophil function provides a novel strategy for the treatment of periodontitis.