未经证实:多项研究表明,炎症性风湿性疾病(IRD)与帕金森病(PD)风险之间的关系不一致。因此,我们进行了一项荟萃分析,以调查不同IRD与PD风险之间的关联.
未经评估:在PubMed上进行了全面搜索,Embase,科克伦图书馆,和WebofScience数据库截至2022年6月。包括报告IRD与PD风险之间关系的研究。使用随机效应模型计算具有95%置信区间(CI)的集合相对风险(RR)。
UNASSIGNED:确定了22篇出版物,涵盖了包含833,004例患者数据的7篇IRD,用于定量分析。合并结果表明,强直性脊柱炎(RR=1.55,95%CI:1.31-1.83,I2=32.1%,P<0.001),干燥综合征(RR=1.34,95%CI:1.22-1.47,I2=58.5%,P<0.001),和Behcet病(RR=1.93,95%CI:1.07-3.49,I2=57.6%,P=0.030)与PD风险增加有关。然而,痛风之间没有观察到明显的关联,类风湿性关节炎,系统性红斑狼疮,以及风湿性多肌痛和随后的PD发展。
未经授权:强直性脊柱炎,干燥综合征,和Behcet病可能增加PD风险。
UNASSIGNED: Several studies showed inconsistencies in the relationships between inflammatory rheumatic diseases (IRDs) and the risk of Parkinson\'s disease (PD). Therefore, we carried out a meta-analysis to investigate the associations between different IRDs and PD risk.
UNASSIGNED: A comprehensive search was undertaken on PubMed, Embase, Cochrane Library, and Web of Science databases up to June 2022. Studies reporting the relationships between IRDs and PD risk were included. Pooled relative risks (RRs) with 95% confidence intervals (CIs) were calculated by using random-effects models.
UNASSIGNED: Twenty-two publications covering seven IRDs containing data from 833,004 patients were identified for quantitative analysis. The pooled results indicated that ankylosing spondylitis (RR = 1.55, 95% CI: 1.31-1.83, I2 = 32.1%, P < 0.001), Sjögren\'s syndrome (RR = 1.34, 95% CI: 1.22-1.47, I2 = 58.5%, P < 0.001), and Behcet\'s disease (RR = 1.93, 95% CI: 1.07-3.49, I2 = 57.6%, P = 0.030) were associated with an increased PD risk. However, no significant associations were observed between gout, rheumatoid arthritis, systemic lupus erythematosus, as well as polymyalgia rheumatica and the subsequent development of PD.
UNASSIGNED: Ankylosing spondylitis, Sjögren\'s syndrome, and Behcet\'s disease may increase PD risk.