Inequality

不等式
  • 文章类型: Journal Article
    目标:受伤或疾病后,物理医学和康复(PM&R)服务通常是帮助患者恢复功能所必需的,活动,和社区参与。十年前,在质量方面,以色列中部的PM&R服务与该国北部农村的PM&R服务之间存在显著差距,数量,和布局。本行政案例报告的目的是概述以色列各地区之间的PM&R服务差距,如上所述;描述十年的民事诉讼;并描述民事诉讼行政方法和行动,这些方法和行动促成了以色列北部现在可用的PM&R服务的变化。
    方法:回顾了十年来促进PM&R服务的民事诉讼,说明了主要的行政步骤,包括发起和组织与主要合作伙伴的会议,游说,在议会和政府委员会面前作证,引起媒体的关注,以提高公众意识,并向以色列最高法院提起诉讼。还描述了遇到的挑战和随后的行动。
    结果:由于我们的行动,人们意识到以色列北部PM&R服务的重要性以及此类服务的不足,有了实际的现场结果,包括计划在2024年开放的180张床位的政府康复中心,以及2020年至2023年开放的5个日托康复诊所和一个私人住院中心。数据驱动的研究将有助于了解当前的差距,并随着新康复设施的开放而跟踪改进。
    结论:当不平等被揭露时,平等立法存在,民事诉讼可以促进变革,以减少这些差距。
    其他人可以遵循本行政案例报告中采取的步骤,以在旨在纠正比较不平等的斗争中取得成功。
    OBJECTIVE: Following an injury or disease, physical medicine and rehabilitation (PM&R) services are often necessary to help patients recover function, activity, and community participation. Ten years ago, there was a significant gap between PM&R services in central Israel and those in the rural north of the country in terms of quality, quantity, and layout. The purpose of this administrative case report is to outline the gap in PM&R services between regions in Israel, as portrayed above; to describe a decade of civil action; and to describe civil action administrative approaches and actions that contributed to changes in the PM&R services now available in northern Israel.
    METHODS: A decade of civil action to promote PM&R services is reviewed, illustrating the main administrative steps, including initiating and organizing meetings with key partners, lobbying, testifying in front of parliament and government committees, garnering media attention to promote public awareness, and filing a case with the Supreme Court of Israel. The encountered challenges and the subsequent actions are also described.
    RESULTS: Awareness of the significance of PM&R services and of the inadequacy of such services in the northern part of Israel rose due to our actions, with practical field results, including an 180-bed government rehabilitation center that plans to open during 2024, and 5 daycare rehabilitation clinics and a private inpatient center that opened between 2020 and 2023. Data-driven research will aid in understanding the current gaps and tracking improvements with the opening of the new rehabilitation facility.
    CONCLUSIONS: When inequality is brought to light, and legislation for equality exists, civil action can promote change to reduce these gaps.
    UNASSIGNED: Others can follow the steps taken in this administrative case report to achieve success in struggles aiming to correct comparative inequality.
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  • 文章类型: Address
    本现场说明审查了利马的灾害风险建设过程,秘鲁。根据COVID-19大流行,考虑了更常见的危险环境。我们提供了基于利马范围内数据的实证分析,并使用单个案例研究解决的结果来说明更一般的结论。我们试图揭示暴露和脆弱性因素如何意味着非常不同的危险,包括COVID-19,主要影响相同的人群。潜在原因和驱动因素,所有这些都与城市不平等的不同表达有关,包括获得合适的城市土地的问题,土地贩运和入侵,国家被排除在社会住房和基本服务之外,不安全的建筑实践和腐败。研究证实了灾害风险社会建构方法的有用性,基于根本原因和驱动因素的概念,以及重新配置城市规划过程的需要,打破部门孤岛,鼓励跨部门和跨空间的综合方法。
    This field note examines the disaster risk construction process in Lima, Peru. More commonly experienced hazard contexts are considered in the light of the COVID-19 pandemic. We provide an empirical analysis based on Lima-wide data and using findings from a single case study settlement to illustrate more general conclusions. We attempt to reveal how exposure and vulnerability factors signify that very different hazards, including COVID-19, predominantly affect the same population groups. Underlying causes and drivers, all related to different expressions of urban inequality, include problems of access to suitable urban land, land trafficking and invasion, State exclusion from social housing and basic services, unsafe building practice and corruption. The research confirms the usefulness of a social construction approach to disaster risk, based on the notion of underlying causes and drivers, and the need to reconfigure urban planning processes, breaking sector silos and encouraging integrated intersectoral and interspatial approaches.
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  • 文章类型: Journal Article
    本文探讨了两种结构性发展的交叉点:监控的增长和“大数据”的兴起。“根据洛杉矶警察局的观察和采访,我提供了一个经验说明,说明采用大数据分析是如何改变警察监控实践的。我认为,采用大数据分析有助于放大先前的监视实践和监视活动的根本转变。首先,使用风险评分对风险的任意评估进行补充和量化。第二,数据用于预测,而不是反应性或解释性的,目的。第三,自动警报系统的普及使得有可能系统地监视前所未有的大量人员。第四,纳入执法数据库的门槛较低,现在包括没有直接警方联系的个人。第五,以前单独的数据系统被合并,促进监督向广泛的机构传播。基于这些发现,我开发了一个大数据监控的理论模型,可以应用于刑事司法系统以外的机构领域。最后,我强调了大数据监控对法律和社会不平等的社会后果。
    This article examines the intersection of two structural developments: the growth of surveillance and the rise of \"big data.\" Drawing on observations and interviews conducted within the Los Angeles Police Department, I offer an empirical account of how the adoption of big data analytics does-and does not-transform police surveillance practices. I argue that the adoption of big data analytics facilitates amplifications of prior surveillance practices and fundamental transformations in surveillance activities. First, discretionary assessments of risk are supplemented and quantified using risk scores. Second, data are used for predictive, rather than reactive or explanatory, purposes. Third, the proliferation of automatic alert systems makes it possible to systematically surveil an unprecedentedly large number of people. Fourth, the threshold for inclusion in law enforcement databases is lower, now including individuals who have not had direct police contact. Fifth, previously separate data systems are merged, facilitating the spread of surveillance into a wide range of institutions. Based on these findings, I develop a theoretical model of big data surveillance that can be applied to institutional domains beyond the criminal justice system. Finally, I highlight the social consequences of big data surveillance for law and social inequality.
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  • 文章类型: Journal Article
    近年来,全球卫生界越来越多地报告了“隐形”问题:健康和福祉方面,特别是在世界上最边缘化和最贫困的人群中,被处于相对权力地位的人和机构系统地忽视和忽视。目前尚不清楚如何在生物伦理学和其他社会科学学科中现实地管理全球健康隐形性并向前迈进。在这封信中,我们反思了几个巴西人经历的隐形案例研究,马来西亚,西非和其他跨国背景。突出了隐形的复杂性及其与社会的相互联系,政治和经济问题和趋势,我们认为,虽然当地和有针对性的干预措施可以在当地提供救济和安慰,他们将无法解决隐形的根本原因。从牛津-约翰霍普金斯大学全球传染病伦理学合作组织(GLIDE)的案例研究报告的共同教训中,我们认为,在处理诸如隐形之类的交叉问题时,二十一世纪的全球健康生物伦理学可以追求一个更“令人不安”的框架,挑战狭隘的安慰解决方案,这些解决方案考虑到社会对现状的不平等。我们强调,令人欣慰和令人不安的生物伦理框架不应被视为对立的一面,但作为两种方法协同工作,以实现国际设定的全球卫生里程碑,为每个人提供更好的健康和福祉。社会学的见解,人类学,后殖民研究,历史,女性主义研究和其他风格的批判性推理长期以来一直困扰着人们及其状况的宏大叙事。为了重新发现世卫组织《阿拉木图宣言》的精神——“到2000年人人享有健康”的愿景——这些思维工具将是必要的帮助,有助于发展合作和支持,超越主导当代全球健康格局的狭隘市场逻辑。
    In recent years, the global health community has increasingly reported the problem of \'invisibility\': aspects of health and wellbeing, particularly amongst the world\'s most marginalized and impoverished people, that are systematically overlooked and ignored by people and institutions in relative positions of power. It is unclear how to realistically manage global health invisibility within bioethics and other social science disciplines and move forward. In this letter, we reflect on several case studies of invisibility experienced by people in Brazil, Malaysia, West Africa and other transnational contexts. Highlighting the complex nature of invisibility and its interconnectedness with social, political and economic issues and trends, we argue that while local and targeted interventions might provide relief and comfort locally, they will not be able to solve the underlying causes of invisibility. Building from the shared lessons of case study presentations at an Oxford-Johns Hopkins Global Infectious Disease Ethics Collaborative (GLIDE), we argue that in dealing with an intersectional issue such as invisibility, twenty-first century global health bioethics could pursue a more \'disturbing\' framework, challenging the narrow comforting solutions which take as a given the sociomaterial inequalities of the status quo. We highlight that comforting and disturbing bioethical frameworks should not be considered as opposing sides, but as two approaches working in tandem in order to achieve the internationally set global health milestones of providing better health and wellbeing for everyone. Insights from sociology, anthropology, postcolonial studies, history, feminist studies and other styles of critical reasoning have long been disturbing to grand narratives of people and their conditions. To rediscover the ethos of the WHO Alma Ata Declaration-a vision of \"health for all by the year 2000\"-these thinking tools will be necessary aids in developing cooperation and support beyond the narrow market logic that dominates the landscape of contemporary global health.
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  • 文章类型: Journal Article
    自1980年代以来,反托拉斯文献就讨论了再生材料购买者之间的市场集中现象。然而,仍然缺乏对供需双方同时集中市场的研究。当扩大生产者责任(EPR)政策产生双边废物产生和价值化市场时,这一点尤其重要。因此,这项研究的目的是探讨发电侧的市场集中度与估值侧的市场份额之间的联系。具体来说,这项研究针对智利商业和工业非危险废物价值化的案例。该分析涵盖了2015年至2019年期间对工业和商业非危险废物进行评估的261家公司。作为智利前10%发电机公司的一部分,与更高的价值市场份额显着相关,在每家公司平均市场份额下降的情况下,价值的总吨位停滞不前,国家一级的价格率下降。
    Market concentration among buyers of recycled materials is a phenomenon discussed since the 1980 s by the anti-trust literature. Yet, there is still a lack of studies on simultaneous market concentration on both the supply and demand sides. This is particularly relevant when Extended Producer Responsibility (EPR) policies produce two-sided waste generation and valorisation markets. Thus, the purpose of this study is to explore the link between market concentration on the generation side and market share on the valorisation side. Specifically, this research addresses the case of valorisation of commercial and industrial non-hazardous waste in Chile. The analysis covers 261 companies that valorised industrial and commercial non-hazardous waste between 2015 and 2019. Being part of the top 10 % of generator companies in Chile is significantly correlated to higher valorisation market share, in a context in which mean market share per company decreased, total tons valorised stagnated, and the country-level valorisation rate diminished.
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  • 文章类型: Journal Article
    这项研究记录了有关传统水果的现有知识,肯尼亚和埃塞俄比亚的蔬菜和豆类。目的是确定具有高粮食安全潜力的被忽视和未充分利用的物种,它们的经济价值和对可持续农业的贡献,基于文献综述和当地专家对现有数据的确认。按优先顺序,肯尼亚排名前5位的水果品种是罗汉,阿丹索尼亚,Sclerocaryabirrea(A.有钱。)Hochst,埃及龟甲(L.)Delile,还有ZiziphusmauritanaLam.,用于蔬菜的是Amaranthusspp。,Vignaunguiculata(L.)沃尔普。,茄属植物。,和CleomegynandraL.埃塞俄比亚的主要水果是Balanitesaegyptiaca(L.)Delile,Ziziphusspina-christi(L.)Desf。,孔雀花草。,科迪亚非洲林。,和MimusopskummelA.DC.,蔬菜是甘蓝型油菜A.Braun,西葫芦,和Amaranthusspp。在这两个国家,优先脉冲物种(无排名)是PhaseoluslunatusL.,Stenostylisstenocarpa(A.有钱。)危害,:)DC。,Lablabpurpureus(L.)Sweet,和Cajanuscajan(L.)Millsp。一般来说,这些优先物种是重要营养素的良好来源,在撒哈拉以南非洲因饮食摄入不足而闻名,代表家庭收入的安全网,并对现有农业系统的生态系统复原力做出积极贡献。完成,需要准确可靠的营养成分数据来提高消费者对其营养和健康益处的认识。由于妇女在传统粮食系统中起着核心作用,他们的赋权,因此,韧性,增加它们对家庭饮食多样性的积极影响。特别是,引入小规模加工技术和营销策略可以增加他们的供应和消费。
    This study documented existing knowledge on traditional fruits, vegetables and pulses in Kenya and Ethiopia. The aim was to identify neglected and underutilized species with high potential for food security, for their economic value and contribution to sustainable agriculture, based on a literature review and confirmation of existing data by local experts. In order of priority, the top 5 fruit species in Kenya are Tamarindus indica L., Adansonia digitata L., Sclerocarya birrea (A.Rich.) Hochst, Balanites aegyptiaca (L.) Delile, and Ziziphus mauritiana Lam., for vegetables are Amaranthus spp., Vigna unguiculata (L.) Walp., Solanum spp., and Cleome gynandra L. Top fruits in Ethiopia are Balanites aegyptiaca (L.) Delile, Ziziphus spina-christi (L.) Desf., Cordeauxia edulis Hemsl., Cordia africana Lam., and Mimusops kummel A. DC., for vegetables are Brassica carinata A. Braun, Cucurbita pepo L., and Amaranthus spp. In both countries, priority pulse species (no ranking) are Phaseolus lunatus L., Sphenostylis stenocarpa (A.Rich.) Harms, Mucuna pruriens (L.) DC., Lablab purpureus (L.) Sweet, and Cajanus cajan (L.) Millsp. Generally, these priority species are good sources of key nutrients known for their inadequate dietary intakes in sub-Saharan Africa, represent a safety net for household income, and contribute positively to ecosystem resilience in existing agricultural systems. Complete, accurate and reliable nutrient composition data are needed to raise consumer awareness about their nutritional and health benefits. Since women play a central role in traditional food systems, their empowerment, and hence resilience, increase the positive impact they can have on the households\' dietary diversity. In particular, introducing small-scale processing techniques and marketing strategies could enhance their supply and consumption.
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  • 文章类型: Journal Article
    背景:很少有研究关注短期暴露于温度与死亡率之间关联的空间聚集区域,这对于识别高易感人群和加强高温/低温的预防很重要。以前的研究已经探索了关联不等式,但是没有研究评估温度归因负担的不平等,这可能对减少与温度相关的区域不平等更有意义。
    方法:以四川盆地(SCB)为例,一个高湿度和四个独特季节的经济不平衡地区,作为一个例子,我们采用了一种新颖的多阶段策略来研究这两个问题。首先,独立构建分布滞后非线性模型,以获得县级每日温度与心肺死亡率之间的关联。然后,使用基于估计误差的空间扫描统计量来检测关联聚类区域.第三,结合已识别的聚集区域以及社会经济和自然因素的多元元回归用于获得稳定的特定县关联。在此基础上绘制了热死亡和冷死亡的地图,并使用浓度指数和洛伦兹曲线评估了它们的不平等。
    结果:平均而言,研究了U型温度-死亡率相关性.检测到一个显著的关联聚类区域(P=0.017),其中高温和低温比非集群区域表现出明显更强的关联,特别是加热温度。因冷死亡(3.5%)明显高于因热死亡(0.5%)。两者都在县之间表现出严重的不平等。在每资本公共预算中也发现了显著的温度归因不平等,城镇化率,就业率和人均国内生产总值。在高温和低温之间,GDP和城市化率的不平等方向相反。
    结论:我们的分析提供了关于温度-死亡率关联的聚类以及冷热负担不平等的第一个证据。在SCB中发现了显着的关联聚集区域和严重的温度归因不等式。农村人口比城市人口承受更重的冷归因死亡风险,但热归因死亡风险较小,建议应设计不同的政策,以减少热和冷温度以及不同地区的温度可归因于的不平等。这种新策略可以为环境暴露与人类健康之间的关联提供有趣的新视角。
    BACKGROUND: Few studies have focused on the spatially clustered regions in the association between short-term exposure to temperature and mortality, which is important for identifying high-susceptibility population and enhancing the prevention of high/low temperatures. Previous studies have explored the association inequality, but no study has evaluated the inequalities of temperature-attributable burdens, which may be more meaningful for reducing temperature-related regional inequality.
    METHODS: Taking the Sichuan Basin (SCB), an economically imbalanced area with high humidity and four distinctive seasons, as an example, we used a novel multi-stage strategy to investigate the two issues. First, distributed lag nonlinear models were independently constructed to obtain the county-level associations between daily temperature and cardiorespiratory mortality. Then, an estimation-error-based spatial scan statistic was used to detect the association-clustered regions. Third, multivariate meta-regression incorporating the identified clustered regions and socioeconomic and natural factors was used to obtain stable county-specific associations, based on which the heat- and cold-attributable deaths were mapped and their inequalities were evaluated using concentration indices and Lorenz curves.
    RESULTS: On average, a U-shaped temperature-mortality association was examined. A significantly association-clustered region was detected (P = 0.017), in which heat and cold temperatures presented significantly stronger associations than those in the non-clustered region, particularly for heat temperatures. The cold-attributable deaths (3.5%) were substantially more than the heat-attributable deaths (0.5%). Both presented severe inequalities over counties. Significant temperature-attributable inequalities were also found over per-capital public budget, urbanization rate, employment rate and per-capital GDP. The directions of inequalities over GDP and urbanization rate were opposite between heat and cold temperatures.
    CONCLUSIONS: Our analysis provided the first evidence about the clustering of temperature-mortality associations and the inequality of cold- and heat-attributable burdens. Significantly association-clustered regions and heavy temperature-attributable inequalities were found in the SCB. Rural people bore heavier cold-attributable but less heat-attributable mortality risk than urban people, suggesting that different policies should be designed to reduce the temperature-attributable inequalities for heat and cold temperatures and different regions. This novel strategy can provide an interesting new perspective in the association between environmental exposure and human health.
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  • 文章类型: Journal Article
    背景:在有关该级别的文献中存在重要差距,不平等,以及低收入和中等收入国家对土著(IH)和非土著(NIH)家庭的金融保护的演变。本文提供了一个评估的水平,社会经济不平等和灾难性中期趋势(CHE),贫困(IHE),以及2008-2020年期间墨西哥IH和NIH的过度(EHE)卫生支出。
    方法:我们使用全国家庭收入和支出调查的最后七波(n=315,829户)进行了汇总横截面分析。我们评估了CHE的社会经济不平等,IHE,和EHE通过根据土著身份估计他们的Wagstaff浓度指数。我们调整了CHE,IHE,和EHE,通过估计具有鲁棒标准误差的最大似然两阶段概率模型。
    结果:我们观察到,在分析期间,CHE,IHE,EHE集中在最贫穷的IH中。CHE从5.4%下降到2008年为4.7%,为3.4%,而不是2014年IHs和NIHs的2.9%,分别,并在2020年之前达到2008年的水平。IHE从2008年到2014年保持不变(IHs为1.6%,而NIHs为1.0%),2016-2020年IHs和NIHs增长40%。EHE在2014年暴跌(IHs为4.6%,而3.8%的NIHs),然后Rose,在2016-2020年期间保持不变(IHs为6.7%,NIHs为5.6%)。
    结论:为了实现全民健康覆盖,卫生当局应制定和实施有效的财政保护机制,以解决结构性不平等问题,特别是包括种族化在内的歧视形式,土著人民等弱势社会群体有系统地面临的问题。这样做将有助于缩小健康方面持续存在的种族差距。
    BACKGROUND: There is an important gap in the literature concerning the level, inequality, and evolution of financial protection for indigenous (IH) and non-indigenous (NIH) households in low- and middle-income countries. This paper offers an assessment of the level, socioeconomic inequality and middle-term trends of catastrophic (CHE), impoverishing (IHE), and excessive (EHE) health expenditures in Mexican IHs and NIHs during the period 2008-2020.
    METHODS: We conducted a pooled cross-sectional analysis using the last seven waves of the National Household Income and Expenditure Survey (n = 315,829 households). We assessed socioeconomic inequality in CHE, IHE, and EHE by estimating their Wagstaff concentration indices according to indigenous status. We adjusted the CHE, IHE, and EHE by estimating a maximum-likelihood two-stage probit model with robust standard errors.
    RESULTS: We observed that, during the period analyzed, CHE, IHE, and EHE were concentrated in the poorest IHs. CHE decreased from 5.4% vs. 4.7% in 2008 to 3.4% vs. 2.9% in 2014 in IHs and NIHs, respectively, and converged at 2008 levels towards 2020. IHE remained unchanged from 2008 to 2014 (1.6% for IHs vs. 1.0% for NIHs) and increased by 40% in IHs and NIHs during 2016-2020. EHE plunged in 2014 (4.6% in IHs vs. 3.8% in NIHs), then rose, and remained unchanged during 2016-2020 (6.7% in IHs and 5.6% in NIHs).
    CONCLUSIONS: In pursuit of universal health coverage, health authorities should formulate and implement effective financial protection mechanisms to address structural inequalities, especially forms of discrimination including racialization, that vulnerable social groups such as indigenous peoples have systematically faced. Doing so would contribute to closing the persistent ethnic gaps in health.
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  • 文章类型: Journal Article
    背景:虽然高收入国家的吸烟率随着时间的推移而下降,吸烟的社会经济不平等已经扩大。这项研究是为数不多的研究与收入相关的吸烟不平等的纵向模式的研究之一,只有第二个在分析中使用集中指数。
    方法:使用集中指数使用北爱尔兰连续家庭调查数据来衡量与收入相关的吸烟不平等。在1985-1995年、1997-2005年和2007-2015年三个时期对吸烟不平等进行了定量和视觉比较。Joinpoint分析用于测量吸烟不平等的总体时间趋势。亚组分析用于检查人口亚组之间吸烟不平等变化的性质。
    结果:在整个1985-2015年期间,吸烟更集中在穷人中(标准浓度指数为-0·131,p<0·001)。虽然患病率在人群中急剧下降,与收入相关的不平等在总体上和分组内急剧增加。在受过高等教育的人群和受雇人群中,与收入相关的吸烟不平等明显更大。在此期间,在采取任何具体政策措施方面没有观察到结构性中断。
    结论:目前的烟草控制方法可能不适合解决吸烟不平等问题,甚至可能适得其反。可能需要采取更有针对性的方法来解决人口分组的具体需求,或者采取更严厉的方法,例如扩大禁令,以进一步降低患病率,同时避免不平等现象的扩大。
    BACKGROUND: While smoking prevalence in high income countries has declined over time, socioeconomic inequalities in smoking have widened. This study is one of the few studies to examine the longitudinal pattern of income-related smoking inequalities and only the second using concentration indices in its analysis.
    METHODS: Income-related smoking inequalities were measured using concentration indices using the Northern Ireland Continuous Household Survey data. Smoking inequalities were compared quantitatively and visually across three periods: 1985-1995, 1997-2005 and 2007-2015. Joinpoint analysis was used to measure the overall time trend of smoking inequalities. Subgroup analysis was used to examine the nature of change in smoking inequalities across population sub-groups.
    RESULTS: Throughout 1985-2015, smoking was more concentrated among the poor (standard concentration index of-0·131, p < 0·001). While prevalence declined sharply across population, income-related inequalities increased sharply in general and within subgroups. Income-related smoking inequalities were significantly larger among high educated group and those who were employed. No structural break was observed with respect to the adoption of any specific policy measures over the period.
    CONCLUSIONS: Current approaches to tobacco control may be ill-suited to addressing smoking inequalities and may indeed be counterproductive. More tailored approaches that address the specific needs of population sub-groups or more draconian approaches such as extensions to prohibition may be required to reduce prevalence further while avoiding a widening of inequalities.
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  • 文章类型: Journal Article
    背景:新抗癌药物的报销时间(TTR)在不同国家之间存在差异,并导致不平等的获得。我们旨在调查新的抗癌药物的TTR,并探讨影响七个高收入欧洲国家报销过程的因素。
    方法:我们从2016年到2021年对具有欧盟市场准入(EU-MA)和人用医药产品委员会的积极意见的抗癌药物进行了回顾性案例研究,并随后获得了国家报销批准(NRA)。德国国家卫生技术评估(HTA)和报销网站,法国,英国,荷兰,比利时,挪威和瑞士被用来识别TTR,定义为从EU-MA到NRA的时间。此外,我们调查了药物-,country-,潜在影响TTR的指标和药物相关因素。
    结果:确定了35种药物,其TTR范围为-81天至2320天(中位数为407天)。在数据截止时,16(46%)在所有七个国家得到了报销。总的来说,最短的TTR在德国(中位数为3天,所有药品报销<5天)。在满足EU-MA(欧盟透明度指令)后,欧洲共同体理事会规定的180天的时间限制,德国100%的包含药品,51%在法国29%在英国和荷兰,14%在瑞士,挪威为6%,比利时为3%。不同国家的TTR差异有统计学意义(P<0.001)。在多变量分析中,与较短的TTR相关的因素是较高的国内生产总值(GDP),缺乏预评估程序和大型制药公司的提交。
    结论:七个高收入欧洲国家之间的抗癌药物的TTR差异很大,导致了获取不平等。在探索的药物中-,country-,与指标和制药相关的因素,我们发现高GDP,缺乏预评估程序和大型制药公司提交的报告与较短的TTR有关.
    Time to reimbursement (TTR) of new anticancer medicines differs between countries and contributes to unequal access. We aimed to investigate TTR of new anticancer medicines and explore factors influencing the reimbursement process in seven high-income European countries.
    We carried out a retrospective case study of anticancer medicines with European Union Market Access (EU-MA) and a positive Committee for Medicinal Products for Human Use opinion from 2016 until 2021 with subsequent national reimbursement approval (NRA). The National Health Technology Assessment (HTA) and reimbursement websites of Germany, France, UK, the Netherlands, Belgium, Norway and Switzerland were used to identify TTR, defined as time from EU-MA to NRA. Additionally, we investigated medication-, country-, indication- and pharma-related factors potentially influencing TTR.
    Thirty-five medicines were identified for which TTR ranged from -81 days to 2320 days (median 407 days). At data cut-off, 16 (46%) were reimbursed in all seven countries. Overall, the shortest TTR was in Germany (median 3 days, all medicines reimbursed <5 days). The time limit for reimbursement of 180 days stated by the Council of European Communities after the EU-MA (EU Transparency Directive) was met for 100% of included medicines in Germany, 51% in France, 29% in the UK and the Netherlands, 14% in Switzerland, 6% in Norway and 3% in Belgium. The TTR was significantly different between countries (P < 0.001). In multivariate analysis, factors associated with shorter TTR were higher gross domestic product (GDP), absence of a pre-assessment procedure and submission by a big pharmaceutical company.
    TTR of anticancer medicines varies significantly between seven high-income European countries and leads to inequality in access. Among explored medication-, country-, indication- and pharma-related factors we found that a high GDP, the absence of a pre-assessment procedure and submission by big pharmaceutical companies were associated with shorter TTR.
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