牛磺酸,由半胱氨酸产生的非必需氨基酸,在身体组织和血浆中含量丰富。它在成长中起着至关重要的作用,渗透,脂质代谢,和神经激素调节。牛磺酸有抗氧化剂,抗凋亡,和抗炎特性,它的缺乏会导致各种疾病,包括心血管疾病,糖尿病,肾,和肝脏疾病。本报告全面综述了牛磺酸在抵消药物诱导的副作用方面的功能特性。跨数据库搜索,如Scopus,PubMed,MEDLINE,WebofScience发表了109篇文章,其中75人被纳入研究。这些结果表明,牛磺酸的保护作用涉及诸如影响Nrf2/OH-1,PI3激酶/AKT和ERK2途径,增强抗氧化剂(SOD,GPx和CAT),和抑制炎症细胞因子(TNF-α,IL-1β和IL-6)。总的来说,补充牛磺酸以及具有明显副作用的药物可以减轻这些影响并增强其功效。对牛磺酸与其他营养素或化合物之间的相互作用的进一步研究可以提供对协同效应和新的治疗方法的见解。
Taurine, a non-essential amino acid produced from cysteine, is abundant in body tissues and blood plasma. It plays vital roles in growth, osmosis, lipid metabolism, and neurohormonal modulation. Taurine has antioxidant, anti-apoptotic, and anti-inflammatory properties, and its deficiency can lead to various diseases including cardiovascular, diabetic, renal, and liver disorders. This report provides a comprehensive
review of the functional properties of taurine in counteracting pharmaceutical-induced side effects. A search across databases such as Scopus, PubMed, MEDLINE, and Web of Science yielded 109 articles, of which 75 were included in the study. These results suggest that the protective effects of taurine involve mechanisms such as influencing pathways of Nrf2/OH-1, PI3-kinase/AKT and ERK2, boosting antioxidants (SOD, GPx and CAT), and suppression of inflammatory cytokines (TNF-α, IL-1β and IL-6). Overall, supplementation with taurine along with medications with significant side effects may mitigate these effects and enhance their efficacy. Further investigation of the interactions between taurine and other nutrients or compounds may provide insights into synergistic effects and novel therapeutic approaches.