默克尔细胞癌(MCC)是一种罕见的原发性神经内分泌皮肤肿瘤,面部呈肉色或蓝红色结节,脖子,或头。长期紫外线照射和Merkel细胞多瘤病毒与MCC发病机制相关。我们介绍了一名87岁男性患者右脸颊上的MCC病例。我们提出这个案子的主要目标是带来MCC,这是一个诊断挑战,引起皮肤科医生和肿瘤学家的注意,因为早期发现和及时治疗很重要。病人有明显的既往病史,包括糖尿病,高血压,血脂异常,慢性肾病3期,良性前列腺增生,慢性低钠血症,急性胰腺炎,羟基脲的原发性血小板增多症,缺血性心脏病.患者出现轻度肿胀的右上唇,显示定义不清,相对均匀的皮下病变,持续1.5个月。临床检查显示,脸颊右侧有5×3厘米的结节性病变,右上唇肿胀。免疫组织化学标记和组织病理学特征证实了MCC的诊断。患者被转诊至肿瘤科进行进一步治疗。皮肤MCC是一种侵袭性病变,具有很高的转移和复发风险,这在免疫功能低下的人群中更为常见。及时管理和治疗MCC至关重要,因为如果不及时治疗,它可以扩散到身体的其他部位,也可以转移到淋巴结和其他器官。患者87岁,有明显的糖尿病既往病史,高血压,血脂异常,慢性肾脏病3期良性前列腺增生,慢性低钠血症,急性胰腺炎,羟基脲的原发性血小板增多症,缺血性心脏病.目前,患者出现轻度肿胀的右上唇,显示定义不清,相对均匀的皮下病变,有1.5个月的存留史。临床检查显示,脸颊右侧有5x3厘米的结节性病变,右上唇肿胀。免疫组织化学标记物结果和组织病理学特征证实了默克尔细胞癌的诊断。患者被转诊至肿瘤科进行进一步治疗。皮肤默克尔细胞癌是一种侵袭性病变,具有很高的转移和复发风险,这在免疫功能低下的人群中更为常见。及时管理和治疗默克尔细胞癌至关重要,因为如果不及时治疗,它可以扩散到身体的其他部位,也可以转移到淋巴结和其他器官。
Merkel cell carcinoma (MCC) is a rare primary neuroendocrine skin tumor that presents as a flesh-colored or bluish-red nodule on the face, neck, or head. Long-term ultraviolet radiation exposure and Merkel cell polyomavirus are associated with MCC pathogenesis. We present a
case of MCC on the right cheek in a male patient aged 87 years. Our primary goal in presenting the
case is to bring MCC, which is a diagnostic challenge, to the notice of dermatologists and oncologists, as early detection and prompt treatment are important. The patient had a significant past medical history, including diabetes mellitus, hypertension, dyslipidemia, stage 3 chronic kidney disease, benign prostatic hyperplasia, chronic hyponatremia, acute pancreatitis, essential thrombocytosis on hydroxyurea, and ischemic heart disease. The patient presented with a mildly swollen right upper lip showing a poorly defined, relatively homogeneous subcutaneous lesion with a history of persistence for 1.5 months. The clinical examination revealed a 5 × 3-cm nodular lesion on the right side of the cheek with swelling of the right upper lip. Immunohistochemistry markers and histopathological features confirmed the diagnosis of MCC. The patient was referred to the oncology department for further management. MCC of the skin is an aggressive lesion with a high risk of metastasis and recurrence, which is more common in immunocompromised people. Prompt management and treatment of MCC is essential because if left untreated, it can spread to other parts of the body and can also metastasize to lymph nodes and other organs. The patient is 87 years old and has a significant past medical history of diabetes mellitus, hypertension, dyslipidemia, chronic kidney disease stage 3, benign prostatic hyperplasia, chronic hyponatremia, acute pancreatitis, essential thrombocytosis on hydroxyurea, and ischemic heart disease. Currently, the patient presented with a mildly swollen right upper lip showing a poorly defined, relatively homogenous subcutaneous lesion with a history of persistence for 1.5 months. The clinical examination revealed a 5x3 cm nodular lesion on the right side of the cheek with swelling of the right upper lip. Immunohistochemistry markers results and histopathological features confirmed the diagnosis of Merkel cell carcinoma. The patient was referred to the oncology department for further management. Merkel cell carcinoma of the skin is an aggressive lesion with a high risk of metastasis and recurrence, which is more common in immunocompromised people. Prompt management and treatment of Merkel cell carcinoma is essential because if left untreated, it can spread to other parts of the body and can also metastasize to lymph nodes and other organs.